Cardiometabolic risk factors among 1.3 million adults with overweight or obesity, but not diabetes, in 10 geographically diverse regions of the United States, 2012-2013

Gregory A. Nichols, Michael Horberg, Corinna Koebnick, Deborah Rohm Young, Beth Waitzfelder, Nancy E. Sherwood, Matthew F. Daley, Assiamira Ferrara

    Research output: Contribution to journalArticle

    Abstract

    Introduction Various phenotypes of overweight and obesity pose various health risks. The objective of this study was to determine the prevalence of 4 commonly measured cardiometabolic risk factors (CRFs) among adults with overweight or obesity, but not diabetes, at the time of the study. Methods We analyzed data for 1,294,174 adults (aged ≥20 y) who were members of one of 4 integrated health systems. Each cohort member had a body mass index in 2012 or 2013 that indicated overweight or obesity. We determined the presence of 4 CRFs within 1 year of the first BMI measurement: elevated blood pressure (systolic ≥130 mm Hg or diastolic > 85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0-405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol ( < 40 mg/dL for men or < 50 mg/dL for women or ICD- 9-CM 272.5); and prediabetes (fasting glucose 100-125 mg/dL or HbA1c 5.7%-6.4% or ICD-9-CM 790.2x). We tested the risk of having 1 or more CRFs after adjusting for obesity class and demographic characteristics with multivariable logistic regression. Results Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis. Conclusion Almost 10% of participants with obesity had no CRFs. Overweight or obesity increases cardiometabolic risk, but the number and type of CRFs varied substantially by age, even among participants with morbid obesity.

    Original languageEnglish (US)
    Article number160438
    JournalPreventing chronic disease
    Volume14
    Issue number3
    DOIs
    StatePublished - 2017

    Fingerprint

    Obesity
    International Classification of Diseases
    Morbid Obesity
    Prediabetic State
    Time and Motion Studies
    Health
    LDL Cholesterol
    HDL Cholesterol
    Fasting
    Triglycerides
    Body Mass Index
    Logistic Models
    Demography
    Blood Pressure
    Phenotype
    Glucose

    ASJC Scopus subject areas

    • Health Policy
    • Public Health, Environmental and Occupational Health

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    Cardiometabolic risk factors among 1.3 million adults with overweight or obesity, but not diabetes, in 10 geographically diverse regions of the United States, 2012-2013. / Nichols, Gregory A.; Horberg, Michael; Koebnick, Corinna; Young, Deborah Rohm; Waitzfelder, Beth; Sherwood, Nancy E.; Daley, Matthew F.; Ferrara, Assiamira.

    In: Preventing chronic disease, Vol. 14, No. 3, 160438, 2017.

    Research output: Contribution to journalArticle

    Nichols, Gregory A. ; Horberg, Michael ; Koebnick, Corinna ; Young, Deborah Rohm ; Waitzfelder, Beth ; Sherwood, Nancy E. ; Daley, Matthew F. ; Ferrara, Assiamira. / Cardiometabolic risk factors among 1.3 million adults with overweight or obesity, but not diabetes, in 10 geographically diverse regions of the United States, 2012-2013. In: Preventing chronic disease. 2017 ; Vol. 14, No. 3.
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    abstract = "Introduction Various phenotypes of overweight and obesity pose various health risks. The objective of this study was to determine the prevalence of 4 commonly measured cardiometabolic risk factors (CRFs) among adults with overweight or obesity, but not diabetes, at the time of the study. Methods We analyzed data for 1,294,174 adults (aged ≥20 y) who were members of one of 4 integrated health systems. Each cohort member had a body mass index in 2012 or 2013 that indicated overweight or obesity. We determined the presence of 4 CRFs within 1 year of the first BMI measurement: elevated blood pressure (systolic ≥130 mm Hg or diastolic > 85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0-405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol ( < 40 mg/dL for men or < 50 mg/dL for women or ICD- 9-CM 272.5); and prediabetes (fasting glucose 100-125 mg/dL or HbA1c 5.7{\%}-6.4{\%} or ICD-9-CM 790.2x). We tested the risk of having 1 or more CRFs after adjusting for obesity class and demographic characteristics with multivariable logistic regression. Results Among participants with overweight (52.5{\%} of the sample), 18.6{\%} had none of the 4 CRFs. Among the 47.5{\%} of participants with obesity, 9.6{\%} had none; among participants with morbid obesity, 5.8{\%} had none. Age was strongly associated with CRFs in multivariable analysis. Conclusion Almost 10{\%} of participants with obesity had no CRFs. Overweight or obesity increases cardiometabolic risk, but the number and type of CRFs varied substantially by age, even among participants with morbid obesity.",
    author = "Nichols, {Gregory A.} and Michael Horberg and Corinna Koebnick and Young, {Deborah Rohm} and Beth Waitzfelder and Sherwood, {Nancy E.} and Daley, {Matthew F.} and Assiamira Ferrara",
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    T1 - Cardiometabolic risk factors among 1.3 million adults with overweight or obesity, but not diabetes, in 10 geographically diverse regions of the United States, 2012-2013

    AU - Nichols, Gregory A.

    AU - Horberg, Michael

    AU - Koebnick, Corinna

    AU - Young, Deborah Rohm

    AU - Waitzfelder, Beth

    AU - Sherwood, Nancy E.

    AU - Daley, Matthew F.

    AU - Ferrara, Assiamira

    PY - 2017

    Y1 - 2017

    N2 - Introduction Various phenotypes of overweight and obesity pose various health risks. The objective of this study was to determine the prevalence of 4 commonly measured cardiometabolic risk factors (CRFs) among adults with overweight or obesity, but not diabetes, at the time of the study. Methods We analyzed data for 1,294,174 adults (aged ≥20 y) who were members of one of 4 integrated health systems. Each cohort member had a body mass index in 2012 or 2013 that indicated overweight or obesity. We determined the presence of 4 CRFs within 1 year of the first BMI measurement: elevated blood pressure (systolic ≥130 mm Hg or diastolic > 85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0-405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol ( < 40 mg/dL for men or < 50 mg/dL for women or ICD- 9-CM 272.5); and prediabetes (fasting glucose 100-125 mg/dL or HbA1c 5.7%-6.4% or ICD-9-CM 790.2x). We tested the risk of having 1 or more CRFs after adjusting for obesity class and demographic characteristics with multivariable logistic regression. Results Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis. Conclusion Almost 10% of participants with obesity had no CRFs. Overweight or obesity increases cardiometabolic risk, but the number and type of CRFs varied substantially by age, even among participants with morbid obesity.

    AB - Introduction Various phenotypes of overweight and obesity pose various health risks. The objective of this study was to determine the prevalence of 4 commonly measured cardiometabolic risk factors (CRFs) among adults with overweight or obesity, but not diabetes, at the time of the study. Methods We analyzed data for 1,294,174 adults (aged ≥20 y) who were members of one of 4 integrated health systems. Each cohort member had a body mass index in 2012 or 2013 that indicated overweight or obesity. We determined the presence of 4 CRFs within 1 year of the first BMI measurement: elevated blood pressure (systolic ≥130 mm Hg or diastolic > 85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0-405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol ( < 40 mg/dL for men or < 50 mg/dL for women or ICD- 9-CM 272.5); and prediabetes (fasting glucose 100-125 mg/dL or HbA1c 5.7%-6.4% or ICD-9-CM 790.2x). We tested the risk of having 1 or more CRFs after adjusting for obesity class and demographic characteristics with multivariable logistic regression. Results Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis. Conclusion Almost 10% of participants with obesity had no CRFs. Overweight or obesity increases cardiometabolic risk, but the number and type of CRFs varied substantially by age, even among participants with morbid obesity.

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