TY - JOUR
T1 - Cardiometabolic disease in South Asians
T2 - A global health concern in an expanding population
AU - Das, A.
AU - Ambale-Venkatesh, B.
AU - Lima, J. A.C.
AU - Freedman, J. E.
AU - Spahillari, A.
AU - Das, R.
AU - Das, S.
AU - Shah, R. V.
AU - Murthy, V. L.
N1 - Publisher Copyright:
© 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity worldwide. As an emerging population, South Asians (SAs) bear a disproportionately high burden of CVD relative to underlying classical risk factors, partly attributable to a greater prevalence of insulin resistance and diabetes and distinct genetic and epigenetic influences. While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA). In this review, we describe the current literature on prevalence, prognosis and CVD risk in SAs, and provide a landscape of translational research in this field toward ameliorating CVD risk in SAs.
AB - Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity worldwide. As an emerging population, South Asians (SAs) bear a disproportionately high burden of CVD relative to underlying classical risk factors, partly attributable to a greater prevalence of insulin resistance and diabetes and distinct genetic and epigenetic influences. While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA). In this review, we describe the current literature on prevalence, prognosis and CVD risk in SAs, and provide a landscape of translational research in this field toward ameliorating CVD risk in SAs.
KW - Adipokines
KW - Cardiovascular disease
KW - Diabetes
KW - Genetics and epigenetics
KW - Metabolic syndrome
KW - Subclinical cardiovascular disease
UR - http://www.scopus.com/inward/record.url?scp=84995394904&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84995394904&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2016.08.001
DO - 10.1016/j.numecd.2016.08.001
M3 - Review article
C2 - 27612985
AN - SCOPUS:84995394904
VL - 27
SP - 32
EP - 40
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 1
ER -