Cardiometabolic disease in South Asians: A global health concern in an expanding population

A. Das, B. Ambale-Venkatesh, J. A.C. Lima, J. E. Freedman, A. Spahillari, R. Das, S. Das, R. V. Shah, V. L. Murthy

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity worldwide. As an emerging population, South Asians (SAs) bear a disproportionately high burden of CVD relative to underlying classical risk factors, partly attributable to a greater prevalence of insulin resistance and diabetes and distinct genetic and epigenetic influences. While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA). In this review, we describe the current literature on prevalence, prognosis and CVD risk in SAs, and provide a landscape of translational research in this field toward ameliorating CVD risk in SAs.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number1
StatePublished - Jan 1 2017


  • Adipokines
  • Cardiovascular disease
  • Diabetes
  • Genetics and epigenetics
  • Metabolic syndrome
  • Subclinical cardiovascular disease

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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