Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function

Research output: Contribution to journalReview articlepeer-review

Abstract

The ability of phospholipids to act as determinants of membrane protein structure and function is probably best exemplified by cardiolipin (CL), the signature phospholipid of mitochondria. Early efforts to reconstitute individual respiratory complexes and members of the mitochondrial carrier family, most notably the ADP/ATP carrier (AAC), often demonstrated the importance of CL. Over the past decade, the significance of CL in the organization of components of the electron transport chain into higher order assemblies, termed respiratory supercomplexes, has been established. Another protein required for oxidative phosphorylation, AAC, has received comparatively little attention likely stemming from the fact that AACs were thought to function in isolation as either homodimers or monomers. Recently however, AACs have been demonstrated to interact with the respiratory supercomplex, other members of the mitochondrial carrier family, and the TIM23 translocon. Interestingly, many if not all of these interactions depend on CL. As the paradigm for the mitochondrial carrier family, these discoveries with AAC suggest that other members of this large group of important proteins may be more gregarious than anticipated. Moreover, it is proposed that AAC and perhaps additional members of the mitochondrial carrier family might represent downstream targets of pathological states involving alterations in CL.

Original languageEnglish (US)
Pages (from-to)2059-2068
Number of pages10
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1788
Issue number10
DOIs
StatePublished - Oct 2009

Keywords

  • ADP/ATP carrier
  • Cardiolipin
  • Mitochondrial carrier family
  • Oxidative phosphorylation
  • Respiratory supercomplex

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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