Cardiac sympathetic neuronal imaging using PET

Riikka Lautamäki, Dnyanesh Tipre, Frank M. Bengel

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Balance of the autonomic nervous system is essential for adequate cardiac performance, and alterations seem to play a key role in the development and progression of various cardiac diseases. PET as an imaging tool: PET imaging of the cardiac autonomic nervous system has advanced extensively in recent years, and multiple pre- and postsynaptic tracers have been introduced. The high spatial and temporal resolution of PET enables noninvasive quantification of neurophysiologic processes at the tissue level. Ligands for catecholamine receptors, along with radiolabeled catecholamines and catecholamine analogs, have been applied to determine involvement of sympathetic dysinnervation at different stages of heart diseases such as ischemia, heart failure, and arrhythmia. Review: This review summarizes the recent findings in neurocardiological PET imaging. Experimental studies with several radioligands and clinical findings in cardiac dysautonomias are discussed.

Original languageEnglish (US)
Pages (from-to)S74-S85
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume34
Issue number1 SUPPL.
DOIs
StatePublished - Jun 2007

Keywords

  • Cardiac autonomic nervous system
  • Catecholamines
  • PET
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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