Cardiac Stem Cells

Biology and Therapeutic Applications

Sarah Selem, Konstantinos E. Hatzistergos, Joshua M. Hare

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter reviews the biology of cardiac stem cells and the growing body of knowledge regarding cell-based therapeutics. Mammalian cardiogenesis involves proper synchrony of function among a diverse population of cells that comprise the heart such as atrial/ventricular cardiomyocytes, smooth muscle cells, endothelial cells, epicardial cells, conduction system cells, valvular components, and connective tissue. The role of cardiac neural crest precursors is ultimately to give rise to the vascular smooth muscle of the aortic arch, ductus arteriosus, and great vessel, as well as to contribute to the cardiac autonomic nervous system. The proepicardial cells give rise to the smooth muscle cells of the coronary vessels and other epicardial cells. Finally, cardiogenic mesodermal precursor(s) are responsible for the formation of the cardiomyocytes and are most likely to be the source of reservoirs of precursor cells post-natally. Currently there are several contemplated mechanisms of actions underlying successful cell-based therapeutics, each with varying degrees of experimental support. These include differentiation, paracrine signaling, fusion, and cell autonomous niche reconstitution. Ex vivo culture of adult and embryonic stem cells under specific conditions such as the hanging drop technique, stimulation by biochemical compounds, or coculture with cardiac myocytes have demonstrated the capacity of stem cells to differentiate into beating cardiomyocytes and vascular lineages.

Original languageEnglish (US)
Title of host publicationPrinciples of Regenerative Medicine
PublisherElsevier Inc.
Pages327-346
Number of pages20
ISBN (Print)9780123814227
DOIs
StatePublished - 2011
Externally publishedYes

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Cytology
Stem cells
Cell Biology
Muscle
Stem Cells
Cardiac Myocytes
Cells
Endothelial cells
Neurology
Arches
Cell culture
Fusion reactions
Therapeutics
Smooth Muscle Myocytes
Tissue
Paracrine Communication
Ductus Arteriosus
Adult Stem Cells
Cell Fusion
Neural Crest

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Selem, S., Hatzistergos, K. E., & Hare, J. M. (2011). Cardiac Stem Cells: Biology and Therapeutic Applications. In Principles of Regenerative Medicine (pp. 327-346). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-381422-7.10019-7

Cardiac Stem Cells : Biology and Therapeutic Applications. / Selem, Sarah; Hatzistergos, Konstantinos E.; Hare, Joshua M.

Principles of Regenerative Medicine. Elsevier Inc., 2011. p. 327-346.

Research output: Chapter in Book/Report/Conference proceedingChapter

Selem, S, Hatzistergos, KE & Hare, JM 2011, Cardiac Stem Cells: Biology and Therapeutic Applications. in Principles of Regenerative Medicine. Elsevier Inc., pp. 327-346. https://doi.org/10.1016/B978-0-12-381422-7.10019-7
Selem S, Hatzistergos KE, Hare JM. Cardiac Stem Cells: Biology and Therapeutic Applications. In Principles of Regenerative Medicine. Elsevier Inc. 2011. p. 327-346 https://doi.org/10.1016/B978-0-12-381422-7.10019-7
Selem, Sarah ; Hatzistergos, Konstantinos E. ; Hare, Joshua M. / Cardiac Stem Cells : Biology and Therapeutic Applications. Principles of Regenerative Medicine. Elsevier Inc., 2011. pp. 327-346
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