Cardiac spectroscopy

Ronald Ouwerkerk

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

energy status of the myocardium. MR Spectroscopy (MRS) explores the chemical shift dimension of the MR signal. MR visible nuclei like 1H–and 31P exhibit slightly shifted resonance frequencies depending on the molecular environment. Thus, compounds can be identified from spectra of these chemical shifts. 31P–MRS was the first method used to investigate cellular metabolism in–vivo, using a simple surface coil. This method was soon adapted for the heart and then used in humans. By observing high-energy phosphate metabolites with 31P-MRS in patients with cardiomyopathies a link was shown between heart failure and changes in the levels of phosphocreatine. Creatine compounds can also be observed with more technically accessible 1H–MRS techniques. With 1H–MRS it is also possible to quantify intra-myocellular triglyceride content. These triglycerides are a major fuel for the heart and abnormal levels are linked to obesity and heart failure. A comprehensive but simple description is given on how to acquire and process in-vivo cardiac MRS data in humans. This chapter will focus on 1H-MRS because this is by far the most accessible technique.

Original languageEnglish (US)
Title of host publicationBasic Principles of Cardiovascular MRI: Physics and Imaging Technique
PublisherSpringer International Publishing
Pages261-269
Number of pages9
ISBN (Print)9783319221410, 9783319221403
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • 1H-MRS
  • 31P-MRS
  • Creatine
  • Magnetic resonance spectroscopy
  • Myocardial metabolism
  • Myocardial triglyceride content
  • Phosphocreatine
  • Triglycerides

ASJC Scopus subject areas

  • Medicine(all)

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