Cardiac rotation and relaxation after anterolateral myocardial infarction

Eike Nagel, Matthias Stuber, Matyas Lakatos, Markus B. Scheidegger, Peter Boesiger, Otto M. Hess

Research output: Contribution to journalArticle

Abstract

Background. Both systolic and diastolic dysfunction have been observed in patients with anterolateral myocardial infarction. Diastolic dysfunction is related to disturbances in relaxation and diastolic filling. Objective. To analyse cardiac rotation, regional shortening and diastolic relaxation in patients with anterolateral infarction. Methods. Cardiac rotation and relaxation in controls and patients with chronic anterolateral infarction were assessed by myocardial tagging. Myocardial tagging is based on magnetic resonance imaging and allows us to label specific myocardial regions for imaging cardiac motion (rotation, translation and radial displacement). A rectangular grid was placed on the myocardium (basal, equatorial and apical short-axis plane) of each of 18 patients with chronic anterolateral infarction and 13 controls. Cardiac rotation, change in area and shortening of circumference were determined in each case. Results. The left ventricle in controls performs a systolic wringing motion with a clockwise rotation at the base and a counterclockwise rotation at the apex when viewed from the apex. During relaxation a rotational motion in the opposite direction (namely untwisting) can be observed. In patients with anterolateral infarction, there is less systolic rotation at the apex and diastolic untwisting is delayed and prolonged in comparison with controls. In the presence of a left ventricular aneurysm (n = 4) apical rotation is completely lost. There is less shortening of circumference in infarcted and remote regions. Conclusions. The wringing motion of the myocardium might be an important mechanism involved in maintaining normal cardiac function with minimal expenditure of energy. This mechanism no longer operates in patients with left ventricular aneurysms and operates significantly less than normal in those with anterolateral hypokinaesia. Diastolic untwisting is significantly delayed and prolonged in patients with anterolateral infarction, which could explain the occurrence of diastolic dysfunction in these patients. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalCoronary Artery Disease
Volume11
Issue number3
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Anterior Wall Myocardial Infarction
Infarction
Aneurysm
Myocardium
Energy Metabolism
Heart Ventricles
Magnetic Resonance Imaging

Keywords

  • Diastolic function
  • Magnetic resonance
  • Myocardial infarction
  • Myocardial tagging
  • Rotational motion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nagel, E., Stuber, M., Lakatos, M., Scheidegger, M. B., Boesiger, P., & Hess, O. M. (2000). Cardiac rotation and relaxation after anterolateral myocardial infarction. Coronary Artery Disease, 11(3), 261-267. https://doi.org/10.1097/00019501-200005000-00009

Cardiac rotation and relaxation after anterolateral myocardial infarction. / Nagel, Eike; Stuber, Matthias; Lakatos, Matyas; Scheidegger, Markus B.; Boesiger, Peter; Hess, Otto M.

In: Coronary Artery Disease, Vol. 11, No. 3, 2000, p. 261-267.

Research output: Contribution to journalArticle

Nagel, E, Stuber, M, Lakatos, M, Scheidegger, MB, Boesiger, P & Hess, OM 2000, 'Cardiac rotation and relaxation after anterolateral myocardial infarction', Coronary Artery Disease, vol. 11, no. 3, pp. 261-267. https://doi.org/10.1097/00019501-200005000-00009
Nagel, Eike ; Stuber, Matthias ; Lakatos, Matyas ; Scheidegger, Markus B. ; Boesiger, Peter ; Hess, Otto M. / Cardiac rotation and relaxation after anterolateral myocardial infarction. In: Coronary Artery Disease. 2000 ; Vol. 11, No. 3. pp. 261-267.
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AU - Nagel, Eike

AU - Stuber, Matthias

AU - Lakatos, Matyas

AU - Scheidegger, Markus B.

AU - Boesiger, Peter

AU - Hess, Otto M.

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N2 - Background. Both systolic and diastolic dysfunction have been observed in patients with anterolateral myocardial infarction. Diastolic dysfunction is related to disturbances in relaxation and diastolic filling. Objective. To analyse cardiac rotation, regional shortening and diastolic relaxation in patients with anterolateral infarction. Methods. Cardiac rotation and relaxation in controls and patients with chronic anterolateral infarction were assessed by myocardial tagging. Myocardial tagging is based on magnetic resonance imaging and allows us to label specific myocardial regions for imaging cardiac motion (rotation, translation and radial displacement). A rectangular grid was placed on the myocardium (basal, equatorial and apical short-axis plane) of each of 18 patients with chronic anterolateral infarction and 13 controls. Cardiac rotation, change in area and shortening of circumference were determined in each case. Results. The left ventricle in controls performs a systolic wringing motion with a clockwise rotation at the base and a counterclockwise rotation at the apex when viewed from the apex. During relaxation a rotational motion in the opposite direction (namely untwisting) can be observed. In patients with anterolateral infarction, there is less systolic rotation at the apex and diastolic untwisting is delayed and prolonged in comparison with controls. In the presence of a left ventricular aneurysm (n = 4) apical rotation is completely lost. There is less shortening of circumference in infarcted and remote regions. Conclusions. The wringing motion of the myocardium might be an important mechanism involved in maintaining normal cardiac function with minimal expenditure of energy. This mechanism no longer operates in patients with left ventricular aneurysms and operates significantly less than normal in those with anterolateral hypokinaesia. Diastolic untwisting is significantly delayed and prolonged in patients with anterolateral infarction, which could explain the occurrence of diastolic dysfunction in these patients. (C) 2000 Lippincott Williams and Wilkins.

AB - Background. Both systolic and diastolic dysfunction have been observed in patients with anterolateral myocardial infarction. Diastolic dysfunction is related to disturbances in relaxation and diastolic filling. Objective. To analyse cardiac rotation, regional shortening and diastolic relaxation in patients with anterolateral infarction. Methods. Cardiac rotation and relaxation in controls and patients with chronic anterolateral infarction were assessed by myocardial tagging. Myocardial tagging is based on magnetic resonance imaging and allows us to label specific myocardial regions for imaging cardiac motion (rotation, translation and radial displacement). A rectangular grid was placed on the myocardium (basal, equatorial and apical short-axis plane) of each of 18 patients with chronic anterolateral infarction and 13 controls. Cardiac rotation, change in area and shortening of circumference were determined in each case. Results. The left ventricle in controls performs a systolic wringing motion with a clockwise rotation at the base and a counterclockwise rotation at the apex when viewed from the apex. During relaxation a rotational motion in the opposite direction (namely untwisting) can be observed. In patients with anterolateral infarction, there is less systolic rotation at the apex and diastolic untwisting is delayed and prolonged in comparison with controls. In the presence of a left ventricular aneurysm (n = 4) apical rotation is completely lost. There is less shortening of circumference in infarcted and remote regions. Conclusions. The wringing motion of the myocardium might be an important mechanism involved in maintaining normal cardiac function with minimal expenditure of energy. This mechanism no longer operates in patients with left ventricular aneurysms and operates significantly less than normal in those with anterolateral hypokinaesia. Diastolic untwisting is significantly delayed and prolonged in patients with anterolateral infarction, which could explain the occurrence of diastolic dysfunction in these patients. (C) 2000 Lippincott Williams and Wilkins.

KW - Diastolic function

KW - Magnetic resonance

KW - Myocardial infarction

KW - Myocardial tagging

KW - Rotational motion

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