Cardiac pseudotumor due to lipomatous hypertrophy of the interatrial septum

Imaging description Lipomatous hypertrophy of the interatrial septum (LHIS) is a benign process of the heart characterized by fatty infiltration of the interatrial septum. The diagnosis is made when fat in the interatrial septum measures greater than 20 mm in thickness and it is usually an incidental finding at cardiac imaging.At echocardiography, LHIS is recognized by echogenic thickening of the interatrial septum. On multiple detector computed tomography (MDCT) (with or without contrast) LHIS is a low-attenuation, < 0 Hounsfield units, bilobed mass with smooth margins that spares the fossa ovalis. It is this sparing of the fossa ovalis which gives this entity its characteristic bilobed or dumbbell-shaped morphology (Figure 2.1). Often, there is cranial extension to the level of the cavoatrial junction and fat may surround the distal superior vena cava (Figure 2.2).On MRI the morphology of LHIS is similar to MDCT. The LHIS demonstrates hyperintensity on T1-weighted imaging with homogenous signal drop out on a fat-suppressed T1 sequence characteristic of macroscopic fat (Figure 2.2). On post-gadolinium sequences no enhancement is seen.FDG uptake within the atrial septum at positron emission tomography (PET) examinations may be seen, and is attributed to the variable presence of brown fat within LHIS (Figure 2.3). It is important to note that the benign FDG uptake in LHIS must not be mistaken for a malignant process such adenopathy or metastatic tumor. Fusion PET-CT will help localize radiotracer uptake to the atrial septum and differentiate it from surrounding structures such as the right hilum, pleura or mediastinum. In difficult cases, it may be necessary to correlate PET-CT findings with either MRI or MDCT in order to prevent inappropriate staging of the patient.ImportanceThe condition of LHIS is a benign incidental finding and typically does not cause any symptoms. Since it may demonstrate increased FDG uptake on PET/CT, it must not be confused with a malignant process, leading to misdiagnosis, inappropriate follow-up imaging or inappropriate biopsy.