Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction

Xian Liang Tang, D. Gregg Rokosh, Yiru Guo, Roberto Bolli

Research output: Contribution to journalReview articlepeer-review

Abstract

Heart failure after myocardial infarction (MI) continues to be the most prevalent cause of morbidity and mortality worldwide. Although pharmaceutical agents and interventional strategies have contributed greatly to therapy, new and superior treatment modalities are urgently needed given the overall disease burden. Stem cell-based therapy is potentially a promising strategy to lead to cardiac repair after MI. An array of cell types has been explored in this respect, including skeletal myoblasts, bone marrow (BM)-derived stem cells, embryonic stem cells, and more recently, cardiac progenitor cells (CPCs). Recently studies have obtained evidence that transplantation of CPCs or BM-derived very small embryonic-like stem cells can improve cardiac function and alleviate cardiac remodeling, supporting the potential therapeutic utility of these cells for cardiac repair. This report summarizes the current data from those studies and discusses the potential implication of these cells in developing clinically-relevant stem cellbased therapeutic strategies for cardiac regeneration.

Original languageEnglish (US)
Pages (from-to)390-404
Number of pages15
JournalCirculation Journal
Volume74
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Cardiac function
  • Cells
  • Ischemic heart disease
  • Myocardial infarction
  • Reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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