Cardiac PET/computed tomography applications and cardiovascular outcome

Thomas Hellmut Schindler

doi:10.1016/j.cpet.2015.03.009

Cardiac PET/computed tomography applications and cardiovascular outcome

Thomas Hellmut Schindler

School of Medicine

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Cardiac PET/computed tomography (CT) in conjunction with different blood flow tracers is increasingly applied for the assessment of myocardial perfusion and myocardial flow reserve (MFR) in the detection of coronary artery disease (CAD). The ability of PET/CT to noninvasively determine regional myocardial blood flow at rest and during vasomotor stress allows the calculation of the MFR, which carries important prognostic information in patients with subclinical forms of cardiomyopathy. The measured MFR optimizes the identification and characterization of the extent and severity of CAD burden, and contributes to the flow-limiting effect of single lesions in multivessel CAD.

Original language	English (US)
Pages (from-to)	441-459
Number of pages	19
Journal	PET Clinics
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/j.cpet.2015.03.009
State	Published - Jul 1 2015

Keywords

CAD
Coronary circulation
Hibernating myocardium
Myocardial blood flow
Myocardial flow reserve
PET/CT
Prognosis
Sarcoid disease

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging

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10.1016/j.cpet.2015.03.009

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title = "Cardiac PET/computed tomography applications and cardiovascular outcome",

abstract = "Cardiac PET/computed tomography (CT) in conjunction with different blood flow tracers is increasingly applied for the assessment of myocardial perfusion and myocardial flow reserve (MFR) in the detection of coronary artery disease (CAD). The ability of PET/CT to noninvasively determine regional myocardial blood flow at rest and during vasomotor stress allows the calculation of the MFR, which carries important prognostic information in patients with subclinical forms of cardiomyopathy. The measured MFR optimizes the identification and characterization of the extent and severity of CAD burden, and contributes to the flow-limiting effect of single lesions in multivessel CAD.",

keywords = "CAD, Coronary circulation, Hibernating myocardium, Myocardial blood flow, Myocardial flow reserve, PET/CT, Prognosis, Sarcoid disease",

author = "Schindler, {Thomas Hellmut}",

note = "Funding Information: Disclosures: Dr Schindler acknowledges all sources of funding as follows: Departmental fund (no. 175470) from Johns Hopkins University, Baltimore, Maryland, USA, and Research grant no. 3200B0-122237 from the Swiss National Science Foundation (SNF; Dr Schindler), with contributions of the Clinical Research Center, University Hospital, and Faculty of Medicine, Geneva and the Louis-Jeantet Foundation; Swiss Heart Foundation; and Gustave and Simone Pr{\'e}vot fund. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2015",

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doi = "10.1016/j.cpet.2015.03.009",

language = "English (US)",

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T1 - Cardiac PET/computed tomography applications and cardiovascular outcome

AU - Schindler, Thomas Hellmut

N1 - Funding Information: Disclosures: Dr Schindler acknowledges all sources of funding as follows: Departmental fund (no. 175470) from Johns Hopkins University, Baltimore, Maryland, USA, and Research grant no. 3200B0-122237 from the Swiss National Science Foundation (SNF; Dr Schindler), with contributions of the Clinical Research Center, University Hospital, and Faculty of Medicine, Geneva and the Louis-Jeantet Foundation; Swiss Heart Foundation; and Gustave and Simone Prévot fund. Publisher Copyright: © 2015 Elsevier Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Cardiac PET/computed tomography (CT) in conjunction with different blood flow tracers is increasingly applied for the assessment of myocardial perfusion and myocardial flow reserve (MFR) in the detection of coronary artery disease (CAD). The ability of PET/CT to noninvasively determine regional myocardial blood flow at rest and during vasomotor stress allows the calculation of the MFR, which carries important prognostic information in patients with subclinical forms of cardiomyopathy. The measured MFR optimizes the identification and characterization of the extent and severity of CAD burden, and contributes to the flow-limiting effect of single lesions in multivessel CAD.

AB - Cardiac PET/computed tomography (CT) in conjunction with different blood flow tracers is increasingly applied for the assessment of myocardial perfusion and myocardial flow reserve (MFR) in the detection of coronary artery disease (CAD). The ability of PET/CT to noninvasively determine regional myocardial blood flow at rest and during vasomotor stress allows the calculation of the MFR, which carries important prognostic information in patients with subclinical forms of cardiomyopathy. The measured MFR optimizes the identification and characterization of the extent and severity of CAD burden, and contributes to the flow-limiting effect of single lesions in multivessel CAD.

KW - CAD

KW - Coronary circulation

KW - Hibernating myocardium

KW - Myocardial blood flow

KW - Myocardial flow reserve

KW - PET/CT

KW - Prognosis

KW - Sarcoid disease

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Cardiac PET/computed tomography applications and cardiovascular outcome

Abstract

Keywords

ASJC Scopus subject areas

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