Cardiac pacing effects on the electrical conduction in isolated rabbit hearts

Suribhotla V. Rajasekhar, Ravi Ranjan, Nitish V Thakor, Morton Maimon Mower

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study presents the effects of cardiac pacing using stimulation pulses of different polarities (anodal, cathodal), strengths and waveshapes (monophasic and biphasic) on the electrical conduction in Langendorff perfused rabbit hearts. We have measured the conduction velocities in the longitudinal and transverse directions to the fiber orientation using bipolar electrograms from 12 epicardial sites. The transmembrane potential changes and the maximum rate of AP upstroke, ((dV/dt)max) under these stimulation conditions are measured using floating tip microelectrodes. The results show a superior performance of biphasic and anodal monophasic pulses that could suggest a novel way to improve myocardial conduction.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages1288
Number of pages1
Volume3
StatePublished - 1996
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth
Duration: Oct 31 1996Nov 3 1996

Other

OtherProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)
CityAmsterdam, Neth
Period10/31/9611/3/96

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Microelectrodes
Fiber reinforced materials
Direction compound

ASJC Scopus subject areas

  • Bioengineering

Cite this

Rajasekhar, S. V., Ranjan, R., Thakor, N. V., & Mower, M. M. (1996). Cardiac pacing effects on the electrical conduction in isolated rabbit hearts. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 3, pp. 1288). IEEE.

Cardiac pacing effects on the electrical conduction in isolated rabbit hearts. / Rajasekhar, Suribhotla V.; Ranjan, Ravi; Thakor, Nitish V; Mower, Morton Maimon.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 3 IEEE, 1996. p. 1288.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rajasekhar, SV, Ranjan, R, Thakor, NV & Mower, MM 1996, Cardiac pacing effects on the electrical conduction in isolated rabbit hearts. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 3, IEEE, pp. 1288, Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5), Amsterdam, Neth, 10/31/96.
Rajasekhar SV, Ranjan R, Thakor NV, Mower MM. Cardiac pacing effects on the electrical conduction in isolated rabbit hearts. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 3. IEEE. 1996. p. 1288
Rajasekhar, Suribhotla V. ; Ranjan, Ravi ; Thakor, Nitish V ; Mower, Morton Maimon. / Cardiac pacing effects on the electrical conduction in isolated rabbit hearts. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 3 IEEE, 1996. pp. 1288
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