Abstract
This study presents the effects of cardiac pacing using stimulation pulses of different polarities (anodal, cathodal), strengths and waveshapes (monophasic and biphasic) on the electrical conduction in Langendorff perfused rabbit hearts. We have measured the conduction velocities in the longitudinal and transverse directions to the fiber orientation using bipolar electrograms from 12 epicardial sites. The transmembrane potential changes and the maximum rate of AP upstroke, ((dV/dt)max) under these stimulation conditions are measured using floating tip microelectrodes. The results show a superior performance of biphasic and anodal monophasic pulses that could suggest a novel way to improve myocardial conduction.
| Original language | English (US) |
|---|---|
| Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Publisher | IEEE |
| Pages | 1288 |
| Number of pages | 1 |
| Volume | 3 |
| State | Published - 1996 |
| Event | Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth Duration: Oct 31 1996 → Nov 3 1996 |
Other
| Other | Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) |
|---|---|
| City | Amsterdam, Neth |
| Period | 10/31/96 → 11/3/96 |
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ASJC Scopus subject areas
- Bioengineering
Cite this
Cardiac pacing effects on the electrical conduction in isolated rabbit hearts. / Rajasekhar, Suribhotla V.; Ranjan, Ravi; Thakor, Nitish V; Mower, Morton Maimon.
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 3 IEEE, 1996. p. 1288.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Cardiac pacing effects on the electrical conduction in isolated rabbit hearts
AU - Rajasekhar, Suribhotla V.
AU - Ranjan, Ravi
AU - Thakor, Nitish V
AU - Mower, Morton Maimon
PY - 1996
Y1 - 1996
N2 - This study presents the effects of cardiac pacing using stimulation pulses of different polarities (anodal, cathodal), strengths and waveshapes (monophasic and biphasic) on the electrical conduction in Langendorff perfused rabbit hearts. We have measured the conduction velocities in the longitudinal and transverse directions to the fiber orientation using bipolar electrograms from 12 epicardial sites. The transmembrane potential changes and the maximum rate of AP upstroke, ((dV/dt)max) under these stimulation conditions are measured using floating tip microelectrodes. The results show a superior performance of biphasic and anodal monophasic pulses that could suggest a novel way to improve myocardial conduction.
AB - This study presents the effects of cardiac pacing using stimulation pulses of different polarities (anodal, cathodal), strengths and waveshapes (monophasic and biphasic) on the electrical conduction in Langendorff perfused rabbit hearts. We have measured the conduction velocities in the longitudinal and transverse directions to the fiber orientation using bipolar electrograms from 12 epicardial sites. The transmembrane potential changes and the maximum rate of AP upstroke, ((dV/dt)max) under these stimulation conditions are measured using floating tip microelectrodes. The results show a superior performance of biphasic and anodal monophasic pulses that could suggest a novel way to improve myocardial conduction.
UR - http://www.scopus.com/inward/record.url?scp=0030314746&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030314746&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0030314746
VL - 3
SP - 1288
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
ER -