Cardiac pacing effects on the electrical conduction in isolated rabbit hearts

Suribhotla V. Rajasekhar; Ravi Ranjan; Nitish V. Thakor; Morton Mower

Cardiac pacing effects on the electrical conduction in isolated rabbit hearts

Suribhotla V. Rajasekhar, Ravi Ranjan, Nitish V. Thakor, Morton Mower

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

Abstract

This study presents the effects of cardiac pacing using stimulation pulses of different polarities (anodal, cathodal), strengths and waveshapes (monophasic and biphasic) on the electrical conduction in Langendorff perfused rabbit hearts. We have measured the conduction velocities in the longitudinal and transverse directions to the fiber orientation using bipolar electrograms from 12 epicardial sites. The transmembrane potential changes and the maximum rate of AP upstroke, ((dV/dt)_max) under these stimulation conditions are measured using floating tip microelectrodes. The results show a superior performance of biphasic and anodal monophasic pulses that could suggest a novel way to improve myocardial conduction.

Original language	English (US)
Number of pages	1
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	3
State	Published - Dec 1 1996
Event	Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth Duration: Oct 31 1996 → Nov 3 1996

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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title = "Cardiac pacing effects on the electrical conduction in isolated rabbit hearts",

abstract = "This study presents the effects of cardiac pacing using stimulation pulses of different polarities (anodal, cathodal), strengths and waveshapes (monophasic and biphasic) on the electrical conduction in Langendorff perfused rabbit hearts. We have measured the conduction velocities in the longitudinal and transverse directions to the fiber orientation using bipolar electrograms from 12 epicardial sites. The transmembrane potential changes and the maximum rate of AP upstroke, ((dV/dt)max) under these stimulation conditions are measured using floating tip microelectrodes. The results show a superior performance of biphasic and anodal monophasic pulses that could suggest a novel way to improve myocardial conduction.",

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note = "Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) ; Conference date: 31-10-1996 Through 03-11-1996",

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AU - Rajasekhar, Suribhotla V.

AU - Ranjan, Ravi

AU - Thakor, Nitish V.

AU - Mower, Morton

PY - 1996/12/1

Y1 - 1996/12/1

N2 - This study presents the effects of cardiac pacing using stimulation pulses of different polarities (anodal, cathodal), strengths and waveshapes (monophasic and biphasic) on the electrical conduction in Langendorff perfused rabbit hearts. We have measured the conduction velocities in the longitudinal and transverse directions to the fiber orientation using bipolar electrograms from 12 epicardial sites. The transmembrane potential changes and the maximum rate of AP upstroke, ((dV/dt)max) under these stimulation conditions are measured using floating tip microelectrodes. The results show a superior performance of biphasic and anodal monophasic pulses that could suggest a novel way to improve myocardial conduction.

AB - This study presents the effects of cardiac pacing using stimulation pulses of different polarities (anodal, cathodal), strengths and waveshapes (monophasic and biphasic) on the electrical conduction in Langendorff perfused rabbit hearts. We have measured the conduction velocities in the longitudinal and transverse directions to the fiber orientation using bipolar electrograms from 12 epicardial sites. The transmembrane potential changes and the maximum rate of AP upstroke, ((dV/dt)max) under these stimulation conditions are measured using floating tip microelectrodes. The results show a superior performance of biphasic and anodal monophasic pulses that could suggest a novel way to improve myocardial conduction.

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