Cardiac myofilaments: From proteome to pathophysiology

Wenhai Jin, Anna T. Brown, Anne M. Murphy

Research output: Contribution to journalReview articlepeer-review


This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.

Original languageEnglish (US)
Pages (from-to)800-810
Number of pages11
JournalProteomics - Clinical Applications
Issue number6
StatePublished - Jun 2008


  • Cardiac ischemia
  • Heart failure
  • Myofilament
  • Post-translational modification

ASJC Scopus subject areas

  • Clinical Biochemistry


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