Cardiac myofilaments: From proteome to pathophysiology

Wenhai Jin; Anna T. Brown; Anne M. Murphy

doi:10.1002/prca.200780075

Cardiac myofilaments: From proteome to pathophysiology

Wenhai Jin, Anna T. Brown, Anne M. Murphy

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.

Original language	English (US)
Pages (from-to)	800-810
Number of pages	11
Journal	Proteomics - Clinical Applications
Volume	2
Issue number	6
DOIs	https://doi.org/10.1002/prca.200780075
State	Published - Jun 2008
Externally published	Yes

Keywords

Cardiac ischemia
Heart failure
Myofilament
Post-translational modification

ASJC Scopus subject areas

Clinical Biochemistry

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10.1002/prca.200780075

Cite this

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title = "Cardiac myofilaments: From proteome to pathophysiology",

abstract = "This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.",

keywords = "Cardiac ischemia, Heart failure, Myofilament, Post-translational modification",

author = "Wenhai Jin and Brown, {Anna T.} and Murphy, {Anne M.}",

year = "2008",

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T2 - From proteome to pathophysiology

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AU - Brown, Anna T.

AU - Murphy, Anne M.

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N2 - This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.

AB - This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.

KW - Cardiac ischemia

KW - Heart failure

KW - Myofilament

KW - Post-translational modification

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Cardiac myofilaments: From proteome to pathophysiology

Abstract

Keywords

ASJC Scopus subject areas

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