Cardiac myocytes and local signaling in nano-domains

Raimond L. Winslow, Joseph L. Greenstein

Research output: Contribution to journalReview articlepeer-review

Abstract

It is well known that calcium-induced calcium-release in cardiac myocytes takes place in spatially restricted regions known as dyads, where discrete patches of junctional sarcoplasmic reticulum tightly associate with the t-tubule membrane. The dimensions of a dyad are so small that it contains only a few Ca 2+ ions at any given time. Ca 2+ signaling in the dyad is therefore noisy, and dominated by the Brownian motion of Ca 2+ ions in a potential field. Remarkably, from this complexity emerges the integrated behavior of the myocyte in which, under normal conditions, precise control of Ca 2+ release and muscle contraction is maintained over the life of the cell. This is but one example of how signal processing within the cardiac myocyte and other cells often occurs in small " nano-domains" where proteins and protein complexes interact at spatial dimensions on the order of ∼1-10 nm and at time-scales on the order of nanoseconds to perform the functions of the cell. In this article, we will review several examples of local signaling in nano-domains, how it contributes to the integrative behavior of the cardiac myocyte, and present computational methods for modeling signal processing within these domains across differing spatio-temporal scales.

Original languageEnglish (US)
Pages (from-to)48-59
Number of pages12
JournalProgress in Biophysics and Molecular Biology
Volume107
Issue number1
DOIs
StatePublished - Oct 2011

Keywords

  • Cardiac myocyte
  • Computational modeling
  • Excitation-contraction coupling
  • Local signaling domain
  • Multi-scale modeling

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology

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