In this study, we used multi-detector computed tomographic (MDCT) images of human left ventricles at end-diastole and end-systole to perform quantitative analysis and comparison of heart motion in patients with anterior wall myocardial infarction and ischemic cardiomyopathy (ICM) versus those with global non-ischemic cardiomyopathy (NICM). MDCT ventricular images of 25 patients (13 with ICM) with ejection fraction (EF) < 35% were analyzed. We used a novel technique (parallel transport) to translate within subject motion-related end-diastole to end-systole deformation to a common coordinate system without incorporating acrosssubject variation. We then performed a hypothesis testing on the ventricular motion variation in the global template coordinate. Statistical analysis indicated that there were meaningful ventricular motion differences between ICM and NICM groups. Additionally, patients with ICM demonstrated less wall thickening at ES in the anterior wall where the pathology was located.