Cardiac magnetic resonance imaging in small rodents using clinical 1.5 T and 3.0 T scanners

Wesley D. Gilson, Dara L. Kraitchman

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac magnetic resonance (CMR) imaging can provide noninvasive, high resolution images of heart anatomy, viability, perfusion, and function. However, the adoption of clinical CMR imaging protocols for small rodents has been limited due to the small heart size and rapid heart rates. Therefore, most CMR studies in small rodents have been performed on non-clinical, high-field MR magnets. Because such high-field systems are not readily available at most institutions, the technical aspects that are needed to perform CMR on clinical 1.5 T and 3.0 T MR scanners are presented in this paper. Equipment requirements are presented, and a comprehensive description of the methods needed to complete a CMR exam including the animal preparation, imaging, and image analysis are discussed. In addition, the advanced applications of myocardial tagging and delayed-contrast-enhanced imaging are reviewed for the assessment of regional contractile function and myocardial viability, respectively.

Original languageEnglish (US)
Pages (from-to)35-45
Number of pages11
JournalMethods
Volume43
Issue number1
DOIs
StatePublished - Sep 2007

Keywords

  • Cardiac MRI
  • Clinical MRI
  • Mice
  • Rats

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)

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