Cardiac events within the 30-day postoperative period is associated with increased 1-year mortality among deceased-donor liver transplant recipients

Theodore W. James, Jessica E.S. Shay, David Furfaro, Burak Ozseker, Stuart D. Russell, Aliaksei Pustavoitau, Nicole Rizkalla, Behnam Saberi, Benjamin Philosophe, Andrew M. Cameron, Ahmet Gurakar

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Each year in the United States, approximately 40 000 patients with a liver disorder will progress to end-stage liver disease and about 30 000 of those patients will subsequently die from this condition. Liver transplant remains the definitive treatment option for end-stage liver disease, and understanding the causes of posttransplant mortality is an ongoing area of investigation. Materials and Methods: In this retrospective cohort study, patients who underwent orthotopic liver transplant between January 2012 and January 2015 at the Johns Hopkins Hospital Liver Transplant Program were reviewed by a single reviewer for cardiac events in the 30 days after transplant or during the index admission. Results: Of the 145 patients included, 30 (20.6%) were identified as having experienced a cardiac event during the defined postoperative period. Overall 1-year mortality for the cohort of 145 patients was 11.7%; however, 1-year mortality in those who had a cardiac event was 36.7% compared with 5.2% in the noncardiac event group (odds ratio = 18.17; P < .001). Although there was a statistically significant difference in age between the groups (58.6 vs 52.3 years old), once accounted for in multivariate analysis, a posttransplant cardiac event was still a statistically significant variable in 1-year mortality (odds ratio = 89.16; 95% confidence interval, 2.71-2933.95; P = .012). Similarly, hepatocellular carcinoma, sex, age, and presence of diabetes had little effect on 1-year mortality when we compared those patients who experienced a cardiac event in the first 30 days versus those who did not (odds ratio = 100.82; 95% confidence interval, 2.15-4726.12; P = .019). Conclusions: Recipients who experience cardiac events within 30 days after transplant have increased 1-year posttransplant mortality. This highlights the importance of cardiac risk stratification before transplant.

Original languageEnglish (US)
Pages (from-to)370-374
Number of pages5
JournalExperimental and Clinical Transplantation
Volume17
Issue number3
DOIs
StatePublished - Jun 2019

Keywords

  • Candidate
  • Coronary artery calcium score
  • Coronary artery disease
  • End-stage liver disease
  • Liver transplantation

ASJC Scopus subject areas

  • Transplantation

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