Cardiac energy metabolism: Models of cellular respiration

M. Saleet Jafri, S. J. Dudycha, B. O'Rourke

Research output: Contribution to journalReview articlepeer-review

Abstract

The heart requires a large amount of energy to sustain both ionic homeostasis and contraction. Under normal conditions, adenosine triphosphate (ATP) production meets this demand. Hence, there is a complex regulatory system that adjusts energy production to meet this demand. However, the mechanisms for this control are a topic of active debate. Energy metabolism can be divided into three main stages: substrate delivery to the tricarboxylic acid (TCA) cycle, the TCA cycle, and oxidative phosphorylation. Each of these processes has multiple control points and exerts control over the other stages. This review discusses the basic stages of energy metabolism, mechanisms of control, and the mathematical and computational models that have been used to study these mechanisms.

Original languageEnglish (US)
Pages (from-to)57-81
Number of pages25
JournalAnnual Review of Biomedical Engineering
Volume3
DOIs
StatePublished - Oct 16 2001
Externally publishedYes

Keywords

  • Computer model
  • Electron transport
  • Glycolysis
  • Oxidative phosphorylation
  • Tricarboxylic acid cycle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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