Cardiac energy metabolism: Models of cellular respiration

M. Saleet Jafri; S. J. Dudycha; B. O'Rourke

doi:10.1146/annurev.bioeng.3.1.57

Cardiac energy metabolism: Models of cellular respiration

M. Saleet Jafri, S. J. Dudycha, B. O'Rourke

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

The heart requires a large amount of energy to sustain both ionic homeostasis and contraction. Under normal conditions, adenosine triphosphate (ATP) production meets this demand. Hence, there is a complex regulatory system that adjusts energy production to meet this demand. However, the mechanisms for this control are a topic of active debate. Energy metabolism can be divided into three main stages: substrate delivery to the tricarboxylic acid (TCA) cycle, the TCA cycle, and oxidative phosphorylation. Each of these processes has multiple control points and exerts control over the other stages. This review discusses the basic stages of energy metabolism, mechanisms of control, and the mathematical and computational models that have been used to study these mechanisms.

Original language	English (US)
Pages (from-to)	57-81
Number of pages	25
Journal	Annual Review of Biomedical Engineering
Volume	3
DOIs	https://doi.org/10.1146/annurev.bioeng.3.1.57
State	Published - 2001
Externally published	Yes

Keywords

Computer model
Electron transport
Glycolysis
Oxidative phosphorylation
Tricarboxylic acid cycle

ASJC Scopus subject areas

Medicine (miscellaneous)
Biomedical Engineering

Access to Document

10.1146/annurev.bioeng.3.1.57

Cite this

@article{c3a3f939d4bc44d585ea21cc59e1e92c,

title = "Cardiac energy metabolism: Models of cellular respiration",

abstract = "The heart requires a large amount of energy to sustain both ionic homeostasis and contraction. Under normal conditions, adenosine triphosphate (ATP) production meets this demand. Hence, there is a complex regulatory system that adjusts energy production to meet this demand. However, the mechanisms for this control are a topic of active debate. Energy metabolism can be divided into three main stages: substrate delivery to the tricarboxylic acid (TCA) cycle, the TCA cycle, and oxidative phosphorylation. Each of these processes has multiple control points and exerts control over the other stages. This review discusses the basic stages of energy metabolism, mechanisms of control, and the mathematical and computational models that have been used to study these mechanisms.",

keywords = "Computer model, Electron transport, Glycolysis, Oxidative phosphorylation, Tricarboxylic acid cycle",

author = "{Saleet Jafri}, M. and Dudycha, {S. J.} and B. O'Rourke",

year = "2001",

doi = "10.1146/annurev.bioeng.3.1.57",

language = "English (US)",

volume = "3",

pages = "57--81",

journal = "Annual Review of Biomedical Engineering",

issn = "1523-9829",

publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Cardiac energy metabolism

T2 - Models of cellular respiration

AU - Saleet Jafri, M.

AU - Dudycha, S. J.

AU - O'Rourke, B.

PY - 2001

Y1 - 2001

N2 - The heart requires a large amount of energy to sustain both ionic homeostasis and contraction. Under normal conditions, adenosine triphosphate (ATP) production meets this demand. Hence, there is a complex regulatory system that adjusts energy production to meet this demand. However, the mechanisms for this control are a topic of active debate. Energy metabolism can be divided into three main stages: substrate delivery to the tricarboxylic acid (TCA) cycle, the TCA cycle, and oxidative phosphorylation. Each of these processes has multiple control points and exerts control over the other stages. This review discusses the basic stages of energy metabolism, mechanisms of control, and the mathematical and computational models that have been used to study these mechanisms.

AB - The heart requires a large amount of energy to sustain both ionic homeostasis and contraction. Under normal conditions, adenosine triphosphate (ATP) production meets this demand. Hence, there is a complex regulatory system that adjusts energy production to meet this demand. However, the mechanisms for this control are a topic of active debate. Energy metabolism can be divided into three main stages: substrate delivery to the tricarboxylic acid (TCA) cycle, the TCA cycle, and oxidative phosphorylation. Each of these processes has multiple control points and exerts control over the other stages. This review discusses the basic stages of energy metabolism, mechanisms of control, and the mathematical and computational models that have been used to study these mechanisms.

KW - Computer model

KW - Electron transport

KW - Glycolysis

KW - Oxidative phosphorylation

KW - Tricarboxylic acid cycle

UR - http://www.scopus.com/inward/record.url?scp=0034814062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034814062&partnerID=8YFLogxK

U2 - 10.1146/annurev.bioeng.3.1.57

DO - 10.1146/annurev.bioeng.3.1.57

M3 - Review article

C2 - 11447057

AN - SCOPUS:0034814062

SN - 1523-9829

VL - 3

SP - 57

EP - 81

JO - Annual Review of Biomedical Engineering

JF - Annual Review of Biomedical Engineering

ER -

Cardiac energy metabolism: Models of cellular respiration

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this