Cardiac elastography: Detecting pathological changes in myocardial tissues

Elisa E. Konofagou, Timothy Harrigan, Scott Solomon

Research output: Contribution to journalConference article

Abstract

Estimation of the mechanical properties of the cardiac muscle has been shown to play a crucial role in the detection of cardiovascular disease. Elastography was recently shown feasible on RF cardiac data in vivo. In this paper, the role of elastography in the detection of ischemia/infarct is explored with simulations and in vivo experiments. In finite-element simulations of a portion of the cardiac muscle containing an infarcted region, the cardiac cycle was simulated with successive compressive and tensile strains ranging between -30% and 20%. The incremental elastic modulus was also mapped using adaptive methods. We then demonstrated this technique utilizing envelope-detected sonographic data (Hewlett-Packard Sonos 5500) in a patient with a known myocardial infarction. In cine-loop and M-Mode elastograms from both normal and infarcted regions in simulations and experiments, the infarcted region was identified by the up to one order of magnitude lower incremental axial displacements and strains, and higher modulus. Information on motion, deformation and mechanical property should constitute a unique tool for noninvasive cardiac diagnosis.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5035
DOIs
StatePublished - Sep 12 2003
Externally publishedYes
EventMedical Imaging 2003: Ultrasonic Imaging and Signal Processing - San Diego, CA, United States
Duration: Feb 18 2003Feb 20 2003

Fingerprint

Cardiac
Cardiac muscle
Muscle
Tissue
muscles
Mechanical properties
Mechanical Properties
Tensile strain
mechanical properties
myocardial infarction
ischemia
Myocardial Infarction
Ischemia
simulation
Elastic moduli
Experiments
Elastic Modulus
Adaptive Method
Finite Element Simulation
Envelope

Keywords

  • Cardiac
  • Contractility
  • Displacement
  • Elastography
  • Modulus
  • Reconstruction
  • Strain

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Cardiac elastography : Detecting pathological changes in myocardial tissues. / Konofagou, Elisa E.; Harrigan, Timothy; Solomon, Scott.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 5035, 12.09.2003, p. 201-210.

Research output: Contribution to journalConference article

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