TY - JOUR
T1 - Cardiac diffusion-weighted MR imaging in recent, subacute, and chronic myocardial infarction
T2 - A pilot study
AU - Laissy, Jean Pierre
AU - Gaxotte, Virginia
AU - Ironde-Laissy, Elisabeth
AU - Klein, Isabelle
AU - Ribet, Aurélie
AU - Bendriss, Ahmed
AU - Chillon, Sylvie
AU - Schouman-Claeys, Elisabeth
AU - Steg, P. Gabriel
AU - Serfaty, Jean Michel
PY - 2013/12
Y1 - 2013/12
N2 - Purpose: To investigate the clinical feasibility of diffusion-weighted imaging (DWI) to detect recent myocardial infarction (MI) and to differentiate it from subacute and chronic MI, with late-gadolinium enhancement (LGE) sequence as reference. Furthermore, to measure variation of the myocardial apparent diffusion coefficient (ADC) according to the age of MI. Materials and Methods: Seventy-four MI patients were separated in 3 groups. Group A included 34 recent (<8 days) MI patients; group B, 22 subacute (9-90 days) MI patients; group C, 18 chronic (> 90 days) MI patients; a fourth group (group D) included 24 controls. DWI and LGE images were acquired on a 1.5T system. DWI and LGE matched images were assessed visually by two blinded observers for hyperintense areas in corresponding segments. Results: Qualitative assessment of DWI compared with LGE images yielded a sensitivity of 97% and a specificity of 61%/14% to differentiate recent from chronic/subacute MI, respectively. The absolute ADCs (recent 0.00632 ± 0.00037 mm2/s, subacute 0.00639 ± 0.00035 mm2/s, chronic 0.00743 ± 0.00056 mm2/s, remote or normal 0.00895 ± 0.00019 mm2/s) and relative ADCs were significantly different between groups (P <0.001) except between recent and subacute MIs. Conclusion: DWI is a sensitive technique to diagnose recent MI. DWI MR sequences could help differentiate recent from chronic MI. From these preliminary results, one should expect DWI to be used in the triage of emergency patients with atypical chest pain, to clarify if an MI is present or not in just a few minutes.
AB - Purpose: To investigate the clinical feasibility of diffusion-weighted imaging (DWI) to detect recent myocardial infarction (MI) and to differentiate it from subacute and chronic MI, with late-gadolinium enhancement (LGE) sequence as reference. Furthermore, to measure variation of the myocardial apparent diffusion coefficient (ADC) according to the age of MI. Materials and Methods: Seventy-four MI patients were separated in 3 groups. Group A included 34 recent (<8 days) MI patients; group B, 22 subacute (9-90 days) MI patients; group C, 18 chronic (> 90 days) MI patients; a fourth group (group D) included 24 controls. DWI and LGE images were acquired on a 1.5T system. DWI and LGE matched images were assessed visually by two blinded observers for hyperintense areas in corresponding segments. Results: Qualitative assessment of DWI compared with LGE images yielded a sensitivity of 97% and a specificity of 61%/14% to differentiate recent from chronic/subacute MI, respectively. The absolute ADCs (recent 0.00632 ± 0.00037 mm2/s, subacute 0.00639 ± 0.00035 mm2/s, chronic 0.00743 ± 0.00056 mm2/s, remote or normal 0.00895 ± 0.00019 mm2/s) and relative ADCs were significantly different between groups (P <0.001) except between recent and subacute MIs. Conclusion: DWI is a sensitive technique to diagnose recent MI. DWI MR sequences could help differentiate recent from chronic MI. From these preliminary results, one should expect DWI to be used in the triage of emergency patients with atypical chest pain, to clarify if an MI is present or not in just a few minutes.
KW - diffusion-weighted imaging
KW - late-gadolinium enhancement
KW - magnetic resonance imaging
KW - myocardial infarction
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U2 - 10.1002/jmri.24125
DO - 10.1002/jmri.24125
M3 - Article
C2 - 23564654
AN - SCOPUS:84890048568
SN - 1053-1807
VL - 38
SP - 1377
EP - 1387
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 6
ER -