Cardiac cell-based therapy

Cell types and mechanisms of actions

Geraldo A. Ramos, Joshua M. Hare

Research output: Contribution to journalArticle

Abstract

Over the past decade, the concept that the heart could undergo cardiac regeneration has rapidly evolved. Studies have indicated that numerous sites in the body harbor stem or progenitor cells, prompting clinical trials of these potential therapeutic cell-based approaches. Most notable are the series of trials utilizing either skeletal myoblasts or autologous whole bone marrow. More recently the quest has focused on specific bone marrow constituents, most notably the mesenchymal stem cell, which has several unique advantages including immunoprivilege, immunosuppression, and the ability to home to areas of tissue injury. Most recently, cells have been identified within the heart itself that are capable of self-replication and differentiation. The discovery of cardiac stem cells offers not only a potential therapeutic approach but also provides a plausible target for endogenous activation as a therapeutic strategy. Together the new insights obtained from studies of cell-based cardiac therapy have ushered in new biological paradigms and enormous potential for novel therapeutic strategies for cardiac disease.

Original languageEnglish (US)
Pages (from-to)951-961
Number of pages11
JournalCell Transplantation
Volume16
Issue number9
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Cell- and Tissue-Based Therapy
Stem cells
Bone
Ports and harbors
Stem Cells
Chemical activation
Tissue
Bone Marrow
Skeletal Myoblasts
Therapeutics
Mesenchymal Stromal Cells
Immunosuppression
Regeneration
Heart Diseases
Clinical Trials
Wounds and Injuries

Keywords

  • Cell therapy
  • Heart failure
  • Myocardial infarction
  • Stem cells

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation

Cite this

Cardiac cell-based therapy : Cell types and mechanisms of actions. / Ramos, Geraldo A.; Hare, Joshua M.

In: Cell Transplantation, Vol. 16, No. 9, 2007, p. 951-961.

Research output: Contribution to journalArticle

Ramos, Geraldo A. ; Hare, Joshua M. / Cardiac cell-based therapy : Cell types and mechanisms of actions. In: Cell Transplantation. 2007 ; Vol. 16, No. 9. pp. 951-961.
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