Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly

Fernando Holguin, Martha M. Téllez-Rojo, Mariana Lazo-Elizondo, David Mannino, Joel Schwartz, Mauricio Hernández, Isabelle Romieu

Research output: Contribution to journalArticle

Abstract

Introduction: Omega-3 fatty acid levels are associated with decreased risk for sudden death; however, the protective cardiovascular mechanisms of omega-3 are poorly understood. This study addresses the heart rate variability (HRV) changes in a cohort of elderly subjects randomized to receive either a daily high dose of marine-derived omega-3 fatty acids (fish oil) or a lower daily dose of a plant-derived omega-3 fatty acid (α-linolenic acid) in soy oil. Methods: A total of 58 elderly nursing home residents were randomized to receive 2 g/d of fish oil capsules vs 2 g/d of soy oil capsules, and were subsequently followed up every other day for a period of 6 months with 6-min measurements of HRV while resting supine. An initial control period of 2 months without supplementation was allowed to establish an HRV baseline for each participant. Results: The average time- and frequency-domain parameters of HRV increased significantly during the supplementation period in both the fish oil and soy oil groups. In the regression model after adjusting for age and mean heart rate, supplementation with fish oil was associated with a significant increase in the high- and low-frequency components, and SD of normal RR intervals (SDNN), whereas only SDNN increased significantly in the soy oil group. Conclusions: Supplementation with 2 g/d of fish oil was well tolerated and was associated with a significant increase in HRV. Supplementation with 2 g/d of soy oil was associated with a lesser but significant increase in HRV.

Original languageEnglish (US)
Pages (from-to)1102-1107
Number of pages6
JournalChest
Volume127
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Fish Oils
Oils
Heart Rate
Omega-3 Fatty Acids
Capsules
Oil and Gas Fields
alpha-Linolenic Acid
Sudden Death
Nursing Homes

Keywords

  • Autonomic
  • Elderly
  • Fish oil
  • Heart rate variability
  • Soy oil

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Holguin, F., Téllez-Rojo, M. M., Lazo-Elizondo, M., Mannino, D., Schwartz, J., Hernández, M., & Romieu, I. (2005). Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly. Chest, 127(4), 1102-1107. https://doi.org/10.1378/chest.127.4.1102

Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly. / Holguin, Fernando; Téllez-Rojo, Martha M.; Lazo-Elizondo, Mariana; Mannino, David; Schwartz, Joel; Hernández, Mauricio; Romieu, Isabelle.

In: Chest, Vol. 127, No. 4, 04.2005, p. 1102-1107.

Research output: Contribution to journalArticle

Holguin, F, Téllez-Rojo, MM, Lazo-Elizondo, M, Mannino, D, Schwartz, J, Hernández, M & Romieu, I 2005, 'Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly', Chest, vol. 127, no. 4, pp. 1102-1107. https://doi.org/10.1378/chest.127.4.1102
Holguin, Fernando ; Téllez-Rojo, Martha M. ; Lazo-Elizondo, Mariana ; Mannino, David ; Schwartz, Joel ; Hernández, Mauricio ; Romieu, Isabelle. / Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly. In: Chest. 2005 ; Vol. 127, No. 4. pp. 1102-1107.
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