Carcinoid of the ampulla of Vater: Morphologic features and clinical implications

George A. Poultside, Wayne A.I. Frederick

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice. The published data indicate that these tumors, in contrast to their midgut counterparts, metastasize in approximately half of cases irrespective of primary tumor size. Therefore, radical excision in the form of pancreaticoduodenectomy is recommended regardless of tumor size. As with other gastrointestinal carcinoid tumors, biological treatment with octreotide analogues can be applied to symptomatic patients. Tumor-targeted radioactive therapy is a newly emerging treatment option. We here report case of a carcinoid tumor of the ampulla of Vater presenting as painless jaundice in a 65-year old man and review the relevant literature, giving special attention to the morphologic features, clinical characteristics, and treatment modalities associated with this disease process.

Original languageEnglish (US)
Pages (from-to)7058-7060
Number of pages3
JournalWorld Journal of Gastroenterology
Issue number43
StatePublished - Nov 21 2006
Externally publishedYes


  • Ampulla of Vater
  • Clinical characteristics
  • Histopathologic features
  • Radical excision

ASJC Scopus subject areas

  • Gastroenterology


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