Carboxy-terminal-extended variant of the human fibrinogen α subunit

A novel exon conferring marked homology to β and γ subunits

Yiping Fu, Lawrence Weissbach, Patricia W. Plant, Carole Oddoux, Yan Cao, T. Jake Liang, Samar N. Roy, Colvin M. Redman, Gerd Grieninger

Research output: Contribution to journalArticle

Abstract

Similarities between the N-terminal regions of the three subunits of the clotting protein fibrinogen - (αβγ)2 - suggest that they evolved from a common progenitor. However, to date no human a chain has been found with the strong C-terminal homology shared by the β and γ chains. Here we examine the natural product of a novel fibrinogen α chain transcript bearing a separate open reading frame that supplies the missing C-terminal homology to the other chains. Additional splicing leads to the use of this extra sequence as a sixth exon elongating the a chain by 35%. Since the extended α chain (αE) is assembled into fibrinogen molecules and its synthesis is enhanced by interleukin-6, it suggests participation in both the acute phase response and normal physiology.

Original languageEnglish (US)
Pages (from-to)11968-11972
Number of pages5
JournalBiochemistry®
Volume31
Issue number48
StatePublished - 1992
Externally publishedYes

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Fibrinogen
Exons
Bearings (structural)
Acute-Phase Reaction
Physiology
Protein Subunits
Biological Products
Open Reading Frames
Interleukin-6
Molecules
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

Fu, Y., Weissbach, L., Plant, P. W., Oddoux, C., Cao, Y., Liang, T. J., ... Grieninger, G. (1992). Carboxy-terminal-extended variant of the human fibrinogen α subunit: A novel exon conferring marked homology to β and γ subunits. Biochemistry®, 31(48), 11968-11972.

Carboxy-terminal-extended variant of the human fibrinogen α subunit : A novel exon conferring marked homology to β and γ subunits. / Fu, Yiping; Weissbach, Lawrence; Plant, Patricia W.; Oddoux, Carole; Cao, Yan; Liang, T. Jake; Roy, Samar N.; Redman, Colvin M.; Grieninger, Gerd.

In: Biochemistry®, Vol. 31, No. 48, 1992, p. 11968-11972.

Research output: Contribution to journalArticle

Fu, Y, Weissbach, L, Plant, PW, Oddoux, C, Cao, Y, Liang, TJ, Roy, SN, Redman, CM & Grieninger, G 1992, 'Carboxy-terminal-extended variant of the human fibrinogen α subunit: A novel exon conferring marked homology to β and γ subunits', Biochemistry®, vol. 31, no. 48, pp. 11968-11972.
Fu, Yiping ; Weissbach, Lawrence ; Plant, Patricia W. ; Oddoux, Carole ; Cao, Yan ; Liang, T. Jake ; Roy, Samar N. ; Redman, Colvin M. ; Grieninger, Gerd. / Carboxy-terminal-extended variant of the human fibrinogen α subunit : A novel exon conferring marked homology to β and γ subunits. In: Biochemistry®. 1992 ; Vol. 31, No. 48. pp. 11968-11972.
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