Carboranyl thymidine analogues for neutron capture therapy

Werner Tjarks, Rohit Tiwari, Youngjoo Byun, Sureshbabu Narayanasamy, Rolf F. Barth

Research output: Contribution to journalArticlepeer-review

Abstract

Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.

Original languageEnglish (US)
Pages (from-to)4978-4991
Number of pages14
JournalChemical Communications
Issue number47
DOIs
StatePublished - 2007

ASJC Scopus subject areas

  • Chemistry(all)

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