Carboranyl thymidine analogues for neutron capture therapy

Werner Tjarks; Rohit Tiwari; Youngjoo Byun; Sureshbabu Narayanasamy; Rolf F. Barth

doi:10.1039/b707257k

Carboranyl thymidine analogues for neutron capture therapy

Werner Tjarks, Rohit Tiwari, Youngjoo Byun, Sureshbabu Narayanasamy, Rolf F. Barth

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.

Original language	English (US)
Pages (from-to)	4978-4991
Number of pages	14
Journal	Chemical Communications
Issue number	47
DOIs	https://doi.org/10.1039/b707257k
State	Published - 2007

ASJC Scopus subject areas

Chemistry(all)

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10.1039/b707257k

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abstract = "Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.",

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AU - Tiwari, Rohit

AU - Byun, Youngjoo

AU - Narayanasamy, Sureshbabu

AU - Barth, Rolf F.

PY - 2007

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