Abstract
Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.
Original language | English (US) |
---|---|
Pages (from-to) | 4978-4991 |
Number of pages | 14 |
Journal | Chemical Communications |
Issue number | 47 |
DOIs | |
State | Published - 2007 |
ASJC Scopus subject areas
- Chemistry(all)