Carboranyl thymidine analogues for neutron capture therapy

Werner Tjarks, Rohit Tiwari, Youngjoo Byun, Sureshbabu Narayanasamy, Rolf F. Barth

Research output: Contribution to journalArticle

Abstract

Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.

Original languageEnglish (US)
Pages (from-to)4978-4991
Number of pages14
JournalChemical Communications
Issue number47
DOIs
StatePublished - 2007

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Thymidine
Neutrons
Boron
Tumors

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Tjarks, W., Tiwari, R., Byun, Y., Narayanasamy, S., & Barth, R. F. (2007). Carboranyl thymidine analogues for neutron capture therapy. Chemical Communications, (47), 4978-4991. https://doi.org/10.1039/b707257k

Carboranyl thymidine analogues for neutron capture therapy. / Tjarks, Werner; Tiwari, Rohit; Byun, Youngjoo; Narayanasamy, Sureshbabu; Barth, Rolf F.

In: Chemical Communications, No. 47, 2007, p. 4978-4991.

Research output: Contribution to journalArticle

Tjarks, W, Tiwari, R, Byun, Y, Narayanasamy, S & Barth, RF 2007, 'Carboranyl thymidine analogues for neutron capture therapy', Chemical Communications, no. 47, pp. 4978-4991. https://doi.org/10.1039/b707257k
Tjarks W, Tiwari R, Byun Y, Narayanasamy S, Barth RF. Carboranyl thymidine analogues for neutron capture therapy. Chemical Communications. 2007;(47):4978-4991. https://doi.org/10.1039/b707257k
Tjarks, Werner ; Tiwari, Rohit ; Byun, Youngjoo ; Narayanasamy, Sureshbabu ; Barth, Rolf F. / Carboranyl thymidine analogues for neutron capture therapy. In: Chemical Communications. 2007 ; No. 47. pp. 4978-4991.
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