Abstract
Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4978-4991 |
| Number of pages | 14 |
| Journal | Chemical Communications |
| Issue number | 47 |
| DOIs | |
| State | Published - 2007 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Carboranyl thymidine analogues for neutron capture therapy. / Tjarks, Werner; Tiwari, Rohit; Byun, Youngjoo; Narayanasamy, Sureshbabu; Barth, Rolf F.
In: Chemical Communications, No. 47, 2007, p. 4978-4991.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Carboranyl thymidine analogues for neutron capture therapy
AU - Tjarks, Werner
AU - Tiwari, Rohit
AU - Byun, Youngjoo
AU - Narayanasamy, Sureshbabu
AU - Barth, Rolf F.
PY - 2007
Y1 - 2007
N2 - Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.
AB - Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.
UR - http://www.scopus.com/inward/record.url?scp=36649020153&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36649020153&partnerID=8YFLogxK
U2 - 10.1039/b707257k
DO - 10.1039/b707257k
M3 - Article
C2 - 18049729
AN - SCOPUS:36649020153
SP - 4978
EP - 4991
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 47
ER -