Carbonic anhydrase IX expression in renal neoplasms: Correlation with tumor type and grade

Elizabeth M. Genega, Musie Ghebremichael, Robert Najarian, Yineng Fu, Yihong Wang, Pedram Argani, Chiara Grisanzio, Sabina Signoretti

Research output: Contribution to journalArticle

Abstract

Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma had focal expression. No staining was seen with other tumors. An association was found between high expression and clear cell vs non-clear cell carcinomas with all cases (P <.01) and primary (P <.01) cases. An association between CAIX expression and grade (P <.01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade.

Original languageEnglish (US)
Pages (from-to)873-879
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume134
Issue number6
DOIs
StatePublished - Dec 2010

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Keywords

  • Carbonic anhydrase IX
  • Clear cell renal cell carcinoma
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Genega, E. M., Ghebremichael, M., Najarian, R., Fu, Y., Wang, Y., Argani, P., Grisanzio, C., & Signoretti, S. (2010). Carbonic anhydrase IX expression in renal neoplasms: Correlation with tumor type and grade. American Journal of Clinical Pathology, 134(6), 873-879. https://doi.org/10.1309/AJCPPPR57HNJMSLZ