TY - JOUR
T1 - Carbonic anhydrase IX expression in renal neoplasms
T2 - Correlation with tumor type and grade
AU - Genega, Elizabeth M.
AU - Ghebremichael, Musie
AU - Najarian, Robert
AU - Fu, Yineng
AU - Wang, Yihong
AU - Argani, Pedram
AU - Grisanzio, Chiara
AU - Signoretti, Sabina
PY - 2010/12
Y1 - 2010/12
N2 - Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma had focal expression. No staining was seen with other tumors. An association was found between high expression and clear cell vs non-clear cell carcinomas with all cases (P < .01) and primary (P < .01) cases. An association between CAIX expression and grade (P < .01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade.
AB - Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma had focal expression. No staining was seen with other tumors. An association was found between high expression and clear cell vs non-clear cell carcinomas with all cases (P < .01) and primary (P < .01) cases. An association between CAIX expression and grade (P < .01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade.
KW - Carbonic anhydrase IX
KW - Clear cell renal cell carcinoma
KW - Renal cell carcinoma
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U2 - 10.1309/AJCPPPR57HNJMSLZ
DO - 10.1309/AJCPPPR57HNJMSLZ
M3 - Article
C2 - 21088149
AN - SCOPUS:78649676646
SN - 0002-9173
VL - 134
SP - 873
EP - 879
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 6
ER -