Carbon-11 labeled radioligands for imaging brain cannabinoid receptors

William B. Mathews, Ursula Scheffel, Paige A. Rauseo, Hayden T. Ravert, Richard A. Frank, George J. Ellames, John M. Herbert, Francis Barth, Murielle Rinaldi-Carmona, Robert F. Dannals

Research output: Contribution to journalArticle

Abstract

Two radioligands, [11C] SR149080 and its morpholino analog [11C] SR149568, were synthesized by reaction of the respective phenolic precursors with [11C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [11C] SR149080 and 1.6 for [11C] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.

Original languageEnglish (US)
Pages (from-to)671-677
Number of pages7
JournalNuclear Medicine and Biology
Volume29
Issue number6
DOIs
StatePublished - Aug 2002

Keywords

  • Antagonist
  • CB1
  • Cannabinoid
  • Carbon-11
  • Mice
  • PET

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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  • Cite this

    Mathews, W. B., Scheffel, U., Rauseo, P. A., Ravert, H. T., Frank, R. A., Ellames, G. J., Herbert, J. M., Barth, F., Rinaldi-Carmona, M., & Dannals, R. F. (2002). Carbon-11 labeled radioligands for imaging brain cannabinoid receptors. Nuclear Medicine and Biology, 29(6), 671-677. https://doi.org/10.1016/S0969-8051(02)00308-6