Two radioligands, [11C] SR149080 and its morpholino analog [11C] SR149568, were synthesized by reaction of the respective phenolic precursors with [11C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [11C] SR149080 and 1.6 for [11C] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research