Carbon-11 labeled radioligands for imaging brain cannabinoid receptors

William B. Mathews, Ursula Scheffel, Paige A. Rauseo, Hayden T Ravert, Richard A. Frank, George J. Ellames, John M. Herbert, Francis Barth, Murielle Rinaldi-Carmona, Robert F. Dannals

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Two radioligands, [11C] SR149080 and its morpholino analog [11C] SR149568, were synthesized by reaction of the respective phenolic precursors with [11C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [11C] SR149080 and 1.6 for [11C] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.

Original languageEnglish (US)
Pages (from-to)671-677
Number of pages7
JournalNuclear Medicine and Biology
Volume29
Issue number6
DOIs
StatePublished - Aug 2002

Keywords

  • Antagonist
  • CB1
  • Cannabinoid
  • Carbon-11
  • Mice
  • PET

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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