Carbohydrate biomarkers for future disease detection and treatment

Yunfeng Cheng; Minyong Li; Shaoru Wang; Hanjing Peng; Suazette Reid; Nanting Ni; Hao Fang; Wenfang Xu; Binghe Wang

doi:10.1007/s11426-010-0021-3

Carbohydrate biomarkers for future disease detection and treatment

Yunfeng Cheng, Minyong Li, Shaoru Wang, Hanjing Peng, Suazette Reid, Nanting Ni, Hao Fang, Wenfang Xu, Binghe Wang

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate "binders" that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging agents. In this review, we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic agents. Examples are arranged based on disease categories including (1) infectious diseases, (2) cancer, (3) inflammation and immune responses, (4) signal transduction, (5) stem cell transformation, (6) embryo development, and (7) cardiovascular diseases, though some issues cross therapeutic boundaries.

Original language	English (US)
Pages (from-to)	3-20
Number of pages	18
Journal	Science China Chemistry
Volume	53
Issue number	1
DOIs	https://doi.org/10.1007/s11426-010-0021-3
State	Published - Jan 2010
Externally published	Yes

Keywords

Biomarkers
Boronolectins
Carbohydrates
Imaging agents

ASJC Scopus subject areas

General Chemistry

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10.1007/s11426-010-0021-3

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title = "Carbohydrate biomarkers for future disease detection and treatment",

abstract = "Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate {"}binders{"} that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging agents. In this review, we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic agents. Examples are arranged based on disease categories including (1) infectious diseases, (2) cancer, (3) inflammation and immune responses, (4) signal transduction, (5) stem cell transformation, (6) embryo development, and (7) cardiovascular diseases, though some issues cross therapeutic boundaries.",

keywords = "Biomarkers, Boronolectins, Carbohydrates, Imaging agents",

author = "Yunfeng Cheng and Minyong Li and Shaoru Wang and Hanjing Peng and Suazette Reid and Nanting Ni and Hao Fang and Wenfang Xu and Binghe Wang",

note = "Funding Information: Financial support for the work conducted in the authors{\textquoteright} lab from the Georgia Cancer Coalition, Georgia Research Alliance, the National Institutes of Health (CA123329, CA113917, DK55062, CA88343, NO1-CO-27184, GM084933, GM086925, and CA122536), and the Molecular Basis of Disease Program at GSU is gratefully acknowledged.",

year = "2010",

month = jan,

doi = "10.1007/s11426-010-0021-3",

language = "English (US)",

volume = "53",

pages = "3--20",

journal = "Science China Chemistry",

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publisher = "Science in China Press",

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T1 - Carbohydrate biomarkers for future disease detection and treatment

AU - Cheng, Yunfeng

AU - Li, Minyong

AU - Wang, Shaoru

AU - Peng, Hanjing

AU - Reid, Suazette

AU - Ni, Nanting

AU - Fang, Hao

AU - Xu, Wenfang

AU - Wang, Binghe

N1 - Funding Information: Financial support for the work conducted in the authors’ lab from the Georgia Cancer Coalition, Georgia Research Alliance, the National Institutes of Health (CA123329, CA113917, DK55062, CA88343, NO1-CO-27184, GM084933, GM086925, and CA122536), and the Molecular Basis of Disease Program at GSU is gratefully acknowledged.

PY - 2010/1

Y1 - 2010/1

N2 - Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate "binders" that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging agents. In this review, we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic agents. Examples are arranged based on disease categories including (1) infectious diseases, (2) cancer, (3) inflammation and immune responses, (4) signal transduction, (5) stem cell transformation, (6) embryo development, and (7) cardiovascular diseases, though some issues cross therapeutic boundaries.

AB - Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate "binders" that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging agents. In this review, we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic agents. Examples are arranged based on disease categories including (1) infectious diseases, (2) cancer, (3) inflammation and immune responses, (4) signal transduction, (5) stem cell transformation, (6) embryo development, and (7) cardiovascular diseases, though some issues cross therapeutic boundaries.

KW - Biomarkers

KW - Boronolectins

KW - Carbohydrates

KW - Imaging agents

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JF - Science China Chemistry

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Carbohydrate biomarkers for future disease detection and treatment

Abstract

Keywords

ASJC Scopus subject areas

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