Abstract
Carbohydrate biomarkers play very important roles in a wide range of biological and pathological processes. Compounds that can specifically recognize a carbohydrate biomarker are useful for targeted delivery of imaging agents and for development of new diagnostics. Furthermore, such compounds could also be candidates for the development of thera - peutic agents. A tremendous amount of active work on synthetic lectin mimics has been reported in recent years. Amongst all the synthetic lectins, boronic-acid-based lectin (boronolectins) have shown great promise. Along this line, four classes of boronolectins including peptide-, nucleic-acid-, polymer-, and small-molecule-based ones are discussed with a focus on the design principles and recent advances. We hope that by presenting the potentials of this field, this review will stimulate more research in this area.
Original language | English (US) |
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Pages (from-to) | 2479-2498 |
Number of pages | 20 |
Journal | Pure and Applied Chemistry |
Volume | 84 |
Issue number | 11 |
DOIs | |
State | Published - 2012 |
Externally published | Yes |
Keywords
- Biomarker recognition
- Boronic acids
- Boronolectins
- Carbohydrates
- Nucleic acids
- Peptides
- Polymers
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering