Carbohydrate biomarker recognition using synthetic lectin mimics

Chaofeng Dai, Arpana Sagwal, Yunfeng Cheng, Hanjing Peng, Weixuan Chen, Binghe Wang

Research output: Contribution to journalArticle

Abstract

Carbohydrate biomarkers play very important roles in a wide range of biological and pathological processes. Compounds that can specifically recognize a carbohydrate biomarker are useful for targeted delivery of imaging agents and for development of new diagnostics. Furthermore, such compounds could also be candidates for the development of thera - peutic agents. A tremendous amount of active work on synthetic lectin mimics has been reported in recent years. Amongst all the synthetic lectins, boronic-acid-based lectin (boronolectins) have shown great promise. Along this line, four classes of boronolectins including peptide-, nucleic-acid-, polymer-, and small-molecule-based ones are discussed with a focus on the design principles and recent advances. We hope that by presenting the potentials of this field, this review will stimulate more research in this area.

Original languageEnglish (US)
Pages (from-to)2479-2498
Number of pages20
JournalPure and Applied Chemistry
Volume84
Issue number11
DOIs
StatePublished - Nov 6 2012
Externally publishedYes

Keywords

  • Biomarker recognition
  • Boronic acids
  • Boronolectins
  • Carbohydrates
  • Nucleic acids
  • Peptides
  • Polymers

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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