Carbenicillin-Induced Acidosis and Seizures

Andrew Whelton; Gordon G. Carter; Mary Ann Garth; Mamdough O. Darwish; W. Gordon Walker

doi:10.1001/jama.1971.03190260056020

Carbenicillin-Induced Acidosis and Seizures

Andrew Whelton, Gordon G. Carter, Mary Ann Garth, Mamdough O. Darwish, W. Gordon Walker

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A patient with chronic, active pyelonephritis was treated with carbenicillin disodium, a drug that is generally accepted as having low toxicity to the central nervous system. While receiving a high dose of the drug the patient developed a combination of acute metabolic acidosis and grand mal seizures. The seizures, and in large part the acute acidosis, were the results of excessively high blood levels of carbenicillin which accumulated in the presence of nonoliguric renal impairment.

Original language	English (US)
Pages (from-to)	1942-1943
Number of pages	2
Journal	Journal of the American Medical Association
Volume	218
Issue number	13
DOIs	https://doi.org/10.1001/jama.1971.03190260056020
State	Published - Dec 27 1971

ASJC Scopus subject areas

Medicine(all)

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