TY - JOUR
T1 - Carbenicillin-Induced Acidosis and Seizures
AU - Whelton, Andrew
AU - Carter, Gordon G.
AU - Garth, Mary Ann
AU - Darwish, Mamdough O.
AU - Walker, W. Gordon
PY - 1971/12/27
Y1 - 1971/12/27
N2 - A patient with chronic, active pyelonephritis was treated with carbenicillin disodium, a drug that is generally accepted as having low toxicity to the central nervous system. While receiving a high dose of the drug the patient developed a combination of acute metabolic acidosis and grand mal seizures. The seizures, and in large part the acute acidosis, were the results of excessively high blood levels of carbenicillin which accumulated in the presence of nonoliguric renal impairment.
AB - A patient with chronic, active pyelonephritis was treated with carbenicillin disodium, a drug that is generally accepted as having low toxicity to the central nervous system. While receiving a high dose of the drug the patient developed a combination of acute metabolic acidosis and grand mal seizures. The seizures, and in large part the acute acidosis, were the results of excessively high blood levels of carbenicillin which accumulated in the presence of nonoliguric renal impairment.
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U2 - 10.1001/jama.1971.03190260056020
DO - 10.1001/jama.1971.03190260056020
M3 - Article
C2 - 5171074
AN - SCOPUS:0015242741
VL - 218
SP - 1942
EP - 1943
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0098-7484
IS - 13
ER -