Carbapenem-Resistant Enterobacteriaceae Infections in Children

Kathleen Chiotos, Jennifer H. Han, Pranita D. Tamma

Research output: Contribution to journalReview articlepeer-review

Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging global public health threat. Infections due to CRE are associated with significant morbidity and mortality. Few therapeutic options are available for treatment of these infections, and optimal antibiotic treatment regimens are unclear. Along with the rapidly increasing prevalence of CRE in the USA and worldwide, several studies have described the epidemiology of CRE in the adult population. While CRE are now also reported sporadically in children, there is a significant lack of data on the epidemiology, risk factors, treatment, and outcomes in this population. This article provides a comprehensive review of what is known to date about CRE, including clinical and molecular epidemiology, microbiologic diagnosis, antibiotic treatment options, and outcomes. In particular, this review will focus on the available data on CRE in the pediatric population.

Original languageEnglish (US)
Article number2
Pages (from-to)1-11
Number of pages11
JournalCurrent Infectious Disease Reports
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Carbapenem-resistant Enterobacteriaceae (CRE)
  • Carbapenemases
  • Gram-negative
  • KPCs
  • Multidrug-resistant organisms
  • Pediatrics
  • Resistant gram-negative bacteria

ASJC Scopus subject areas

  • Infectious Diseases

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