Capturing Cardiogenesis in Gastruloids

Giuliana Rossi, Nicolas Broguiere, Matthew Miyamoto, Andrea Boni, Romain Guiet, Mehmet Girgin, Robert G. Kelly, Chulan Kwon, Matthias P. Lutolf

Research output: Contribution to journalArticlepeer-review

Abstract

Rossi et al. describe an embryonic organoid model that mimics the early development of the heart, from the generation of cardiovascular precursor cells to the specification of the first and second heart fields. These axially patterned organoids support the formation of cardiac crescent and early cardiac tube-like structures while reproducing the cell diversity and tissue-tissue interactions typical of embryos.

Original languageEnglish (US)
JournalCell stem cell
DOIs
StateAccepted/In press - 2020

Keywords

  • 3D cardiac tissue
  • cardiac organoid
  • cardiogenesis
  • development
  • embryonic organoids
  • heart
  • in vitro organogenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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