@article{d06766039c6f49e185b2b6b29c3c1ffb,
title = "Capturing Cardiogenesis in Gastruloids",
abstract = "Rossi et al. describe an embryonic organoid model that mimics the early development of the heart, from the generation of cardiovascular precursor cells to the specification of the first and second heart fields. These axially patterned organoids support the formation of cardiac crescent and early cardiac tube-like structures while reproducing the cell diversity and tissue-tissue interactions typical of embryos.",
keywords = "3D cardiac tissue, cardiac organoid, cardiogenesis, development, embryonic organoids, heart, in vitro organogenesis",
author = "Giuliana Rossi and Nicolas Broguiere and Matthew Miyamoto and Andrea Boni and Romain Guiet and Mehmet Girgin and Kelly, {Robert G.} and Chulan Kwon and Lutolf, {Matthias P.}",
note = "Funding Information: We thank Alfonso Martinez Arias for great support throughout the project. We thank Denis Duboule and Nadia Mercader for useful feedback on the manuscript. We thank Gioele La Manno for helpful discussion on single-cell RNA-seq. We thank members of the Lutolf laboratory for discussions and sharing materials, C{\'e}dric Blanpain (ULB) for providing Mesp1-GFP cells, Alexander Medvinsky (MRC Edinburgh) for providing Flk1-GFP cells, Andrew Oates (EPFL) and Peter Strnad (Viventis Microscopy S{\`a}rl) for making light-sheet LS1 Live microscope available and for technical support, Olivier Burri for EasyXT development, Thierry Laroche for support with Z1 light-sheet imaging, Arne Seitz and other members of Bioimaging and Optics Facility (EPFL) for microscopy support, Jessica Sordet-Dessimoz and Gian-Filippo Mancini from Histology Core Facility for RNAscope, and all personnel of Histology Core Facility, Flow Cytometry Core Facility, and Gene Expression Core Facility (EPFL) for their technical support. This work was funded by EPFL . ",
year = "2020",
doi = "10.1016/j.stem.2020.10.013",
language = "English (US)",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
}