Capsular polysaccharides of Cryptococcus neoformans.

A. K. Bhattacharjee; J. E. Bennett; C. P. Glaudemans

doi:10.1093/clinids/6.5.619

Capsular polysaccharides of Cryptococcus neoformans.

A. K. Bhattacharjee, J. E. Bennett, C. P. Glaudemans

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Polysaccharides of Cryptococcus neoformans are considered to have a role in the virulence of this encapsulated fungus. The structure has been determined for the most abundant polysaccharide, a glucuronoxylomannan of varying xylose and ester content. The structural complexity of the capsular material increases from serotype D to A to B to C, but even for the simplest capsule (type D), the immunodeterminants seem to occur only on the side chains. The interactions of some of these groups with antibodies is discussed.

Original language	English (US)
Pages (from-to)	619-624
Number of pages	6
Journal	Reviews of infectious diseases
Volume	6
Issue number	5
DOIs	https://doi.org/10.1093/clinids/6.5.619
State	Published - Jan 1 1984

ASJC Scopus subject areas

Microbiology (medical)

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10.1093/clinids/6.5.619

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AB - Polysaccharides of Cryptococcus neoformans are considered to have a role in the virulence of this encapsulated fungus. The structure has been determined for the most abundant polysaccharide, a glucuronoxylomannan of varying xylose and ester content. The structural complexity of the capsular material increases from serotype D to A to B to C, but even for the simplest capsule (type D), the immunodeterminants seem to occur only on the side chains. The interactions of some of these groups with antibodies is discussed.

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