Capsaicin treatment differentially affects feeding suppression by bombesin-like peptides

Ellen E. Ladenheim, Susan Knipp

Research output: Contribution to journalArticlepeer-review

Abstract

Peripheral administration of bombesin (BN) and the related mammalian peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB), suppress food intake in rats. To examine whether all BN-like peptides utilize the same neural pathways to reduce feeding, rats were treated on postnatal day 2 with the injection vehicle or capsaicin, a neurotoxin that damages a subset of visceral afferent fibers. When rats reached adulthood, we compared the ability of a dose range of systemically administered BN, GRP18-27 and NMB to reduce intake of a 0.5 kcal/ml glucose solution in a short-term feeding test. Our results demonstrate that capsaicin treatment abolished or attenuated the suppression of glucose intake produced by BN and NMB but had no effect on the ability of GRP to reduce feeding. These results suggest that different neural substrates underlie the anorexic effects of peripherally administered BN-like peptides.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalPhysiology and Behavior
Volume91
Issue number1
DOIs
StatePublished - May 16 2007

Keywords

  • Bombesin
  • Capsaicin
  • Food intake
  • Gastrin-releasing peptide: Neuromedin B

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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