Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors

Research output: Contribution to journalArticle

Abstract

The recently cloned vanilloid receptor (VR1) is postulated to account for heat and capsaicin sensitivity in unmyelinated afferents. We sought to determine whether heat and capsaicin sensitivity also coexist in myelinated nociceptive afferents. Action potential (AP) activity was recorded from single A-fiber nociceptors that innervated the hairy skin in monkey. Before intradermal injection of capsaicin (10 μg/10 μl) into the receptive field, nociceptors were classified as heat-sensitive (threshold, ≤53°C, 1 sec) or heat-insensitive afferents and as mechanically sensitive (von Frey threshold,

Original languageEnglish (US)
Pages (from-to)4460-4468
Number of pages9
JournalJournal of Neuroscience
Volume21
Issue number12
StatePublished - Jun 15 2001

Fingerprint

Myelinated Nerve Fibers
Nociceptors
Capsaicin
Hot Temperature
Intradermal Injections
Action Potentials
Haplorhini
Skin

Keywords

  • Capsaicin
  • Hairy skin
  • Heat sensitivity
  • Mechanically insensitive afferents
  • Monkey
  • Myelinated nociceptors
  • Primate
  • Receptive field

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors. / Ringkamp, Matthias; Peng, Y. B.; Wu, Gang; Hartke, T. V.; Campbell, James N; Meyer, Richard.

In: Journal of Neuroscience, Vol. 21, No. 12, 15.06.2001, p. 4460-4468.

Research output: Contribution to journalArticle

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