Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans

Peter Rasmussen, Ellen A. Dawson, Lars Nybo, Johannes J. Van Lieshout, Niels H. Secher, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

Brain function requires oxygen and maintenance of brain capillary oxygenation is important. We evaluated how faithfully frontal lobe near-infrared spectroscopy (NIRS) follows haemoglobin saturation (SCap) and how calculated mitochondrial oxygen tension (PMitoO2) influences motor performance. Twelve healthy subjects (20 to 29 years), supine and seated, inhaled O2 air-mixtures (10% to 100%) with and without added 5% carbon dioxide and during hyperventilation. Two measures of frontal lobe oxygenation by NIRS (NIRO-200 and INVOS) were compared with capillary oxygen saturation (SCap) as calculated from the O2 content of brachial arterial and right internal jugular venous blood. At control S Cap (78%±4%; mean±s.d.) was halfway between the arterial (98%±1%) and jugular venous oxygenation (SvO 2; 61%±6%). Both NIRS devices monitored SCap (PvO2 increased from 39%±5% to 79%±7% with an increase in the transcranial ultrasound Doppler determined middle cerebral artery flow velocity from 29±8 to 65±15 cm/sec. When SCap fell below ∼70% with reduced flow and inspired oxygen tension, PMitoO2 decreased (PMitoO2 (r> 0.74; P

Original languageEnglish (US)
Pages (from-to)1082-1093
Number of pages12
JournalJournal of Cerebral Blood Flow and Metabolism
Volume27
Issue number5
DOIs
StatePublished - May 16 2007
Externally publishedYes

Fingerprint

Near-Infrared Spectroscopy
Frontal Lobe
Oxygen
Neck
Doppler Ultrasonography
Hyperventilation
Middle Cerebral Artery
Brain
Carbon Dioxide
Healthy Volunteers
Hemoglobins
Arm
Air
Maintenance
Equipment and Supplies

Keywords

  • Activation
  • Cerebral blood flow
  • Hypercapnia
  • Hypocapnia
  • Hypoxia
  • Jugular vein

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

Cite this

Rasmussen, P., Dawson, E. A., Nybo, L., Van Lieshout, J. J., Secher, N. H., & Gjedde, A. (2007). Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. Journal of Cerebral Blood Flow and Metabolism, 27(5), 1082-1093. https://doi.org/10.1038/sj.jcbfm.9600416

Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. / Rasmussen, Peter; Dawson, Ellen A.; Nybo, Lars; Van Lieshout, Johannes J.; Secher, Niels H.; Gjedde, Albert.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 27, No. 5, 16.05.2007, p. 1082-1093.

Research output: Contribution to journalArticle

Rasmussen, P, Dawson, EA, Nybo, L, Van Lieshout, JJ, Secher, NH & Gjedde, A 2007, 'Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans', Journal of Cerebral Blood Flow and Metabolism, vol. 27, no. 5, pp. 1082-1093. https://doi.org/10.1038/sj.jcbfm.9600416
Rasmussen, Peter ; Dawson, Ellen A. ; Nybo, Lars ; Van Lieshout, Johannes J. ; Secher, Niels H. ; Gjedde, Albert. / Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. In: Journal of Cerebral Blood Flow and Metabolism. 2007 ; Vol. 27, No. 5. pp. 1082-1093.
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