TY - JOUR
T1 - Capillary leak syndrome in children with C4A-deficiency undergoing cardiac surgery with cardiopulmonary bypass
T2 - A double-blind, randomised controlled study
AU - Zhang, Shihai
AU - Wang, Shouyong
AU - Li, Qing
AU - Yao, Shanglong
AU - Zeng, Bangxiong
AU - Ziegelstein, Roy C.
AU - Hu, Qinghua
N1 - Funding Information:
We thank all the patients, patients' parents, doctors, and nurses who participated in this study. We also thank Prof Ping Yin for statistical expertise and Prof Kuang-Chung Wong for advice and review of the study. This study was supported by Grant 30271255 from the National Natural Science Foundation of China to S Zhang.
PY - 2005/8/13
Y1 - 2005/8/13
N2 - Background: Capillary leak syndrome is a life-threatening complication after cardiopulmonary bypass (CPB), with an incidence of about 4-37% in children worldwide. On the basis of previous results, we undertook a randomised controlled study to investigate the priming with plasma rich in the C4A isotype of complement component 4 on the incidence of capillary leak syndrome in children with C4A deficiency. Methods: In a hospital in Wuhan, China, we randomly assigned 116 neonates, infants, and children lacking complement component C4A to receive C4A-free or C4A-rich plasma priming (n=58 each, 20 mL/kg). The primary outcome was capillary leak syndrome, identified as an increased transvascular escape rate of Evans blue dye from plasma. Concentrations of activated complement components C4 and C3, inflammatory mediators interleukin 6, interleukin 8, tumour necrosis factor (TNF) α, plasma protein, and PaO2/FIO2 ratios (ratio of the partial arterial pressure of oxygen to the fractional concentration of oxygen in inspired air) were measured before and 4 h after CPB. Analysis was by intention to treat. Findings: Three (5%) patients given C4A-rich plasma priming had capillary leak syndrome compared with 56 (97%) given C4A-free plasma (p<0·0001). At 4 h after CPB, activated C4, interleukin 6, interleukin 8, and TNFα concentrations were higher, whereas PaO2/F IO2 ratios and plasma protein concentrations were significantly lower in the C4A-free group than changes in the C4A-rich group. Activated C3 rose equally in both groups. Activated C4 significantly correlated with interleukin 6, interleukin 8, and TNFα concentrations; PaO 2/FIO2 ratios; and the escape rate of Evans blue dye at 4 h after CPB. Two patients in the C4A-free group died of respiratory and renal failure on day 3 after CPB. Interpretation: In paediatric patients with C4A deficiency, C4A-rich plasma priming reduces the incidence of CPB-related capillary leak syndrome by blocking the activated C4 increase and attenuating the systemic inflammatory response after CPB.
AB - Background: Capillary leak syndrome is a life-threatening complication after cardiopulmonary bypass (CPB), with an incidence of about 4-37% in children worldwide. On the basis of previous results, we undertook a randomised controlled study to investigate the priming with plasma rich in the C4A isotype of complement component 4 on the incidence of capillary leak syndrome in children with C4A deficiency. Methods: In a hospital in Wuhan, China, we randomly assigned 116 neonates, infants, and children lacking complement component C4A to receive C4A-free or C4A-rich plasma priming (n=58 each, 20 mL/kg). The primary outcome was capillary leak syndrome, identified as an increased transvascular escape rate of Evans blue dye from plasma. Concentrations of activated complement components C4 and C3, inflammatory mediators interleukin 6, interleukin 8, tumour necrosis factor (TNF) α, plasma protein, and PaO2/FIO2 ratios (ratio of the partial arterial pressure of oxygen to the fractional concentration of oxygen in inspired air) were measured before and 4 h after CPB. Analysis was by intention to treat. Findings: Three (5%) patients given C4A-rich plasma priming had capillary leak syndrome compared with 56 (97%) given C4A-free plasma (p<0·0001). At 4 h after CPB, activated C4, interleukin 6, interleukin 8, and TNFα concentrations were higher, whereas PaO2/F IO2 ratios and plasma protein concentrations were significantly lower in the C4A-free group than changes in the C4A-rich group. Activated C3 rose equally in both groups. Activated C4 significantly correlated with interleukin 6, interleukin 8, and TNFα concentrations; PaO 2/FIO2 ratios; and the escape rate of Evans blue dye at 4 h after CPB. Two patients in the C4A-free group died of respiratory and renal failure on day 3 after CPB. Interpretation: In paediatric patients with C4A deficiency, C4A-rich plasma priming reduces the incidence of CPB-related capillary leak syndrome by blocking the activated C4 increase and attenuating the systemic inflammatory response after CPB.
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U2 - 10.1016/S0140-6736(05)67099-7
DO - 10.1016/S0140-6736(05)67099-7
M3 - Article
C2 - 16099291
AN - SCOPUS:23744483507
SN - 0140-6736
VL - 366
SP - 556
EP - 562
JO - Lancet
JF - Lancet
IS - 9485
ER -