Capacity of purified antigens and whole pollen extracts to release histamine from leukocytes of hay fever patients

Philip S. Norman, Lawrence M. Lichtenstein

Research output: Contribution to journalArticle

Abstract

Eighty-seven consecutive patients appearing with complaints suggestive of spring and fall hay fever were subjected to basophil histamine release study with 4 antigenic preparations: whole ragweed extract, antigen E of ragweed, mixed grass pollen extract, and Group I antigen of rye grass. Among the 87 patients, 12 failed to release histamine to ragweed extract or antigen E and 16 failed to release histamine to grass extract or Group I. Among the remaining patients 5 reacted to whole ragweed extract but not antigen E and 2 reacted to mixed grass extract but not Group I. The patients with this pattern were all at the lower end of the spectrum of sensitivity for the crude extracts. These data tend to confirm that antigen E and Group I are the antigens of prime importance in the majority of hay fever patients with ragweed and grass pollen sensitivity respectively.

Original languageEnglish (US)
Pages (from-to)94-104
Number of pages11
JournalThe Journal of allergy and clinical immunology
Volume52
Issue number2
DOIs
StatePublished - Aug 1973

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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