Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle.

J. F. Casella, S. W. Craig, D. J. Maack, A. E. Brown

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Various biological activities have been attributed to actin-capping proteins based on their in vitro effects on actin filaments. However, there is little direct evidence for their in vivo activities. In this paper, we show that Cap Z(36/32), a barbed end, actin-capping protein isolated from muscle (Casella, J. F., D. J. Maack, and S. Lin, 1986, J. Biol. Chem., 261:10915-10921) is localized to the barbed ends of actin filaments by electron microscopy and to the Z-line of chicken skeletal muscle by indirect immunofluorescence and electron microscopy. Since actin filaments associate with the Z-line at their barbed ends, these findings suggest that Cap Z(36/32) may play a role in regulating length, orienting, or attaching actin filaments to Z-discs.

Original languageEnglish (US)
Pages (from-to)371-379
Number of pages9
JournalThe Journal of cell biology
Issue number1
StatePublished - Jul 1987


ASJC Scopus subject areas

  • Cell Biology

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