Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects

Yasmin L. Hurd, Olivier J. Manzoni, Mikhail V. Pletnikov, Francis S. Lee, Sagnik Bhattacharyya, Miriam Melis

Research output: Contribution to journalArticle

Abstract

The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women and adolescents. Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposure to delta-9-tetrahydrocannabinol, the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including in vivo neuroimaging strategies.

Original languageEnglish (US)
Pages (from-to)8250-8258
Number of pages9
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Volume39
Issue number42
DOIs
StatePublished - Oct 16 2019

Fingerprint

Cannabis
Brain
Dronabinol
Mental Health
Vulnerable Populations
Genetic Polymorphisms
Epigenomics
Neuroimaging
Substance-Related Disorders
Psychiatry
Pregnant Women
Epidemiologic Studies
Genotype

Keywords

  • adolescence
  • cannabis
  • cognition
  • perinatal
  • psychiatric disorders
  • reward

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cannabis and the Developing Brain : Insights into Its Long-Lasting Effects. / Hurd, Yasmin L.; Manzoni, Olivier J.; Pletnikov, Mikhail V.; Lee, Francis S.; Bhattacharyya, Sagnik; Melis, Miriam.

In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 39, No. 42, 16.10.2019, p. 8250-8258.

Research output: Contribution to journalArticle

Hurd, Yasmin L. ; Manzoni, Olivier J. ; Pletnikov, Mikhail V. ; Lee, Francis S. ; Bhattacharyya, Sagnik ; Melis, Miriam. / Cannabis and the Developing Brain : Insights into Its Long-Lasting Effects. In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 ; Vol. 39, No. 42. pp. 8250-8258.
@article{81fcbfe729c34ded8b93da468fbf563c,
title = "Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects",
abstract = "The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women and adolescents. Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposure to delta-9-tetrahydrocannabinol, the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including in vivo neuroimaging strategies.",
keywords = "adolescence, cannabis, cognition, perinatal, psychiatric disorders, reward",
author = "Hurd, {Yasmin L.} and Manzoni, {Olivier J.} and Pletnikov, {Mikhail V.} and Lee, {Francis S.} and Sagnik Bhattacharyya and Miriam Melis",
year = "2019",
month = "10",
day = "16",
doi = "10.1523/JNEUROSCI.1165-19.2019",
language = "English (US)",
volume = "39",
pages = "8250--8258",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "42",

}

TY - JOUR

T1 - Cannabis and the Developing Brain

T2 - Insights into Its Long-Lasting Effects

AU - Hurd, Yasmin L.

AU - Manzoni, Olivier J.

AU - Pletnikov, Mikhail V.

AU - Lee, Francis S.

AU - Bhattacharyya, Sagnik

AU - Melis, Miriam

PY - 2019/10/16

Y1 - 2019/10/16

N2 - The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women and adolescents. Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposure to delta-9-tetrahydrocannabinol, the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including in vivo neuroimaging strategies.

AB - The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women and adolescents. Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposure to delta-9-tetrahydrocannabinol, the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including in vivo neuroimaging strategies.

KW - adolescence

KW - cannabis

KW - cognition

KW - perinatal

KW - psychiatric disorders

KW - reward

UR - http://www.scopus.com/inward/record.url?scp=85073430352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073430352&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.1165-19.2019

DO - 10.1523/JNEUROSCI.1165-19.2019

M3 - Article

C2 - 31619494

AN - SCOPUS:85073430352

VL - 39

SP - 8250

EP - 8258

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 42

ER -