TY - JOUR
T1 - Cannabis and the developing brain
T2 - Insights into its long-lasting effects
AU - Hurd, Yasmin L.
AU - Manzoni, Olivier J.
AU - Pletnikov, Mikhail V.
AU - Lee, Francis S.
AU - Bhattacharyya, Sagnik
AU - Melis, Miriam
N1 - Funding Information:
This work was supported by Institut National de la Santé et de la Recherche Médicale Agence National de la RecherchetoO.J.M.;NationalInstitutesofHealth,NationalInstituteofDrugAbuseDA030359toY.L.H.,DA044925to M.M., DA043982 to O.J.M., DA046196 to O.J.M., and DA041208 to M.V.P.; National Institutes of Health, National Institute of Mental Health MH094268 and MH083728 to M.V.P.; National Institutes of Health NS052819 to F.S.L.; National Institute for Health Research 16/126/53 to S.B.; Medical Research Council to S.B.; National Institutes of Health, Mental Health Biomedical Research Centre at South London, and Maudsley National Health Service Foundation Trust and King’s College London to S.B. The authors declare no competing financial interests.
Publisher Copyright:
© 2019 the author.
PY - 2019/10/16
Y1 - 2019/10/16
N2 - The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women and adolescents. Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposureto delta-9-tetrahydrocannabinol,the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including in vivo neuroimaging strategies.
AB - The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women and adolescents. Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposureto delta-9-tetrahydrocannabinol,the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including in vivo neuroimaging strategies.
KW - Adolescence
KW - Cannabis
KW - Cognition
KW - Perinatal
KW - Psychiatric Disorders
KW - Reward
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U2 - 10.1523/JNEUROSCI.1165-19.2019
DO - 10.1523/JNEUROSCI.1165-19.2019
M3 - Article
C2 - 31619494
AN - SCOPUS:85073430352
SN - 0270-6474
VL - 39
SP - 8250
EP - 8258
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 42
ER -