Cannabinoid CB2 Receptor: A New Target for Treatment of Cocaine Addiction

Haiying Zhang, Z. X. Xi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cocaine addiction is a serious social and biomedical problem worldwide, and, so far, there is no effective medication available for clinic use. Given an important role of brain cannabinoid CB1 receptor (CB1R) in drug reward and addiction, the majority of cannabinoid-based medication development studies have focused on brain CB1R. In addition to CB1R, growing evidence suggests that CB2R is also expressed in the brain, particularly in dopamine (DA) neurons in the ventral tegmental area (VTA). Activation of CB2R inhibits VTA DA neuronal activities, DA release in the nucleus accumbens, and intravenous cocaine self-administration. Furthermore, chronic cocaine administration significantly upregulates neuronal CB2R expression in the brain and in VTA DA neurons, suggesting that brain CB2R may constitute a new therapeutic target in the treatment of cocaine addiction. In this chapter, we review the recent progress in brain CB2R research, focusing on the role of brain CB2R in drug abuse and addiction.

Original languageEnglish (US)
Title of host publicationThe Neuroscience of Cocaine
Subtitle of host publicationMechanisms and Treatment
PublisherElsevier Inc.
Pages689-698
Number of pages10
ISBN (Electronic)9780128037928
ISBN (Print)9780128037508
DOIs
StatePublished - May 16 2017
Externally publishedYes

Fingerprint

Cannabinoid Receptor CB2
Cocaine-Related Disorders
Cannabinoid Receptor CB1
Brain
Ventral Tegmental Area
Substance-Related Disorders
Dopaminergic Neurons
Cocaine
Therapeutics
Dopamine
Self Administration
Cannabinoids
Social Problems
Nucleus Accumbens
Reward
Up-Regulation

Keywords

  • Addiction
  • Cannabinoid
  • CB receptor
  • Cocaine
  • Dopamine
  • Self-administration

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Zhang, H., & Xi, Z. X. (2017). Cannabinoid CB2 Receptor: A New Target for Treatment of Cocaine Addiction. In The Neuroscience of Cocaine: Mechanisms and Treatment (pp. 689-698). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803750-8.00070-1

Cannabinoid CB2 Receptor : A New Target for Treatment of Cocaine Addiction. / Zhang, Haiying; Xi, Z. X.

The Neuroscience of Cocaine: Mechanisms and Treatment. Elsevier Inc., 2017. p. 689-698.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zhang, H & Xi, ZX 2017, Cannabinoid CB2 Receptor: A New Target for Treatment of Cocaine Addiction. in The Neuroscience of Cocaine: Mechanisms and Treatment. Elsevier Inc., pp. 689-698. https://doi.org/10.1016/B978-0-12-803750-8.00070-1
Zhang H, Xi ZX. Cannabinoid CB2 Receptor: A New Target for Treatment of Cocaine Addiction. In The Neuroscience of Cocaine: Mechanisms and Treatment. Elsevier Inc. 2017. p. 689-698 https://doi.org/10.1016/B978-0-12-803750-8.00070-1
Zhang, Haiying ; Xi, Z. X. / Cannabinoid CB2 Receptor : A New Target for Treatment of Cocaine Addiction. The Neuroscience of Cocaine: Mechanisms and Treatment. Elsevier Inc., 2017. pp. 689-698
@inbook{d49ea874078944aaaf53d4d8b341aca3,
title = "Cannabinoid CB2 Receptor: A New Target for Treatment of Cocaine Addiction",
abstract = "Cocaine addiction is a serious social and biomedical problem worldwide, and, so far, there is no effective medication available for clinic use. Given an important role of brain cannabinoid CB1 receptor (CB1R) in drug reward and addiction, the majority of cannabinoid-based medication development studies have focused on brain CB1R. In addition to CB1R, growing evidence suggests that CB2R is also expressed in the brain, particularly in dopamine (DA) neurons in the ventral tegmental area (VTA). Activation of CB2R inhibits VTA DA neuronal activities, DA release in the nucleus accumbens, and intravenous cocaine self-administration. Furthermore, chronic cocaine administration significantly upregulates neuronal CB2R expression in the brain and in VTA DA neurons, suggesting that brain CB2R may constitute a new therapeutic target in the treatment of cocaine addiction. In this chapter, we review the recent progress in brain CB2R research, focusing on the role of brain CB2R in drug abuse and addiction.",
keywords = "Addiction, Cannabinoid, CB receptor, Cocaine, Dopamine, Self-administration",
author = "Haiying Zhang and Xi, {Z. X.}",
year = "2017",
month = "5",
day = "16",
doi = "10.1016/B978-0-12-803750-8.00070-1",
language = "English (US)",
isbn = "9780128037508",
pages = "689--698",
booktitle = "The Neuroscience of Cocaine",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Cannabinoid CB2 Receptor

T2 - A New Target for Treatment of Cocaine Addiction

AU - Zhang, Haiying

AU - Xi, Z. X.

PY - 2017/5/16

Y1 - 2017/5/16

N2 - Cocaine addiction is a serious social and biomedical problem worldwide, and, so far, there is no effective medication available for clinic use. Given an important role of brain cannabinoid CB1 receptor (CB1R) in drug reward and addiction, the majority of cannabinoid-based medication development studies have focused on brain CB1R. In addition to CB1R, growing evidence suggests that CB2R is also expressed in the brain, particularly in dopamine (DA) neurons in the ventral tegmental area (VTA). Activation of CB2R inhibits VTA DA neuronal activities, DA release in the nucleus accumbens, and intravenous cocaine self-administration. Furthermore, chronic cocaine administration significantly upregulates neuronal CB2R expression in the brain and in VTA DA neurons, suggesting that brain CB2R may constitute a new therapeutic target in the treatment of cocaine addiction. In this chapter, we review the recent progress in brain CB2R research, focusing on the role of brain CB2R in drug abuse and addiction.

AB - Cocaine addiction is a serious social and biomedical problem worldwide, and, so far, there is no effective medication available for clinic use. Given an important role of brain cannabinoid CB1 receptor (CB1R) in drug reward and addiction, the majority of cannabinoid-based medication development studies have focused on brain CB1R. In addition to CB1R, growing evidence suggests that CB2R is also expressed in the brain, particularly in dopamine (DA) neurons in the ventral tegmental area (VTA). Activation of CB2R inhibits VTA DA neuronal activities, DA release in the nucleus accumbens, and intravenous cocaine self-administration. Furthermore, chronic cocaine administration significantly upregulates neuronal CB2R expression in the brain and in VTA DA neurons, suggesting that brain CB2R may constitute a new therapeutic target in the treatment of cocaine addiction. In this chapter, we review the recent progress in brain CB2R research, focusing on the role of brain CB2R in drug abuse and addiction.

KW - Addiction

KW - Cannabinoid

KW - CB receptor

KW - Cocaine

KW - Dopamine

KW - Self-administration

UR - http://www.scopus.com/inward/record.url?scp=85054896660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054896660&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-803750-8.00070-1

DO - 10.1016/B978-0-12-803750-8.00070-1

M3 - Chapter

AN - SCOPUS:85054896660

SN - 9780128037508

SP - 689

EP - 698

BT - The Neuroscience of Cocaine

PB - Elsevier Inc.

ER -