Canine neuroaxonal dystrophy

Linda C. Cork, Juan C Troncoso, Donald L. Price, Elis F. Stanley, John W. Griffin

Research output: Contribution to journalArticle

Abstract

Canine neuroaxonal dystrophy, a newly recognized familial disorder in Rottweiler dogs, is characterized by progressive sensory ataxia. Two of four dogs studied clinically were autopsied and the cerebellum was mildly atrophic. Massive numbers of axonal spheroids were present in many regions of the neuraxis but were most prominent in the dorsal horn of the spinal cord and the nuclei gracilis and cuneatus. Ultrastructurally, spheroids appeared to be swellings of distal axons which were filled with accumulations of smooth membrane-bound vesicles, membranous lamellae, dense bodies, and other organelles. Neuropathological changes were similar to those identified in human neuroaxonal dystrophy.

Original languageEnglish (US)
Pages (from-to)286-296
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume42
Issue number3
StatePublished - 1983

Fingerprint

Neuroaxonal Dystrophies
Canidae
Dogs
Ataxia
Organelles
Cerebellum
Axons
Membranes

Keywords

  • Axonal
  • Axons
  • Axons
  • Dogs
  • Dystrophic
  • Neuroaxonal dystrophy
  • Rottweiler
  • Spheroid
  • Transport

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Cork, L. C., Troncoso, J. C., Price, D. L., Stanley, E. F., & Griffin, J. W. (1983). Canine neuroaxonal dystrophy. Journal of Neuropathology and Experimental Neurology, 42(3), 286-296.

Canine neuroaxonal dystrophy. / Cork, Linda C.; Troncoso, Juan C; Price, Donald L.; Stanley, Elis F.; Griffin, John W.

In: Journal of Neuropathology and Experimental Neurology, Vol. 42, No. 3, 1983, p. 286-296.

Research output: Contribution to journalArticle

Cork, LC, Troncoso, JC, Price, DL, Stanley, EF & Griffin, JW 1983, 'Canine neuroaxonal dystrophy', Journal of Neuropathology and Experimental Neurology, vol. 42, no. 3, pp. 286-296.
Cork LC, Troncoso JC, Price DL, Stanley EF, Griffin JW. Canine neuroaxonal dystrophy. Journal of Neuropathology and Experimental Neurology. 1983;42(3):286-296.
Cork, Linda C. ; Troncoso, Juan C ; Price, Donald L. ; Stanley, Elis F. ; Griffin, John W. / Canine neuroaxonal dystrophy. In: Journal of Neuropathology and Experimental Neurology. 1983 ; Vol. 42, No. 3. pp. 286-296.
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