Canine inherited ataxia: Ultrastructural observations

Juan C. Troncoso, Linda C. Cork, Donald L. Price

Research output: Contribution to journalArticlepeer-review


Canine Inherited Ataxia is inherited as an autosomal recessive trait in Gordon Setters. This animal model shares features with certain human cerebellar degenerations and offers the opportunity to examine brain tissue at various stages during the evolution of disease. The present investigation focuses on the morphometric and ultrastructural changes of cerebellar neurons. Purkinje and granule cells are the principal intrinsic neurons at risk. The size of Purkinje cells decreases, axonal degeneration is an important feature of the pathology, and synaptic abnormalities occur in the cerebellar glomeruli and deep nuclei of the cerebellum. The sequence and nature of synaptic changes in the molecular layer suggest that the degenerative process begins in Purkinje cells and that granule cells may be secondarily affected.

Original languageEnglish (US)
Pages (from-to)165-175
Number of pages11
JournalJournal of neuropathology and experimental neurology
Issue number2
StatePublished - Mar 1985


  • Ataxia
  • Cerebellum
  • Dogs
  • Gordon Setters
  • Granule cell
  • Hereditary diseases
  • Purkinje cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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