TY - JOUR
T1 - Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women
AU - Lee, Ji Young
AU - Park, Ae Kyung
AU - Lee, Kyoung Mu
AU - Park, Sue K.
AU - Han, Sohee
AU - Han, Wonshik
AU - Noh, Dong Young
AU - Yoo, Keun Young
AU - Kim, Ho
AU - Chanock, Stephen J.
AU - Rothman, Nathaniel
AU - Kang, Daehee
N1 - Funding Information:
Korea Health 21 R&D Project, Ministry for Health, Welfare and family affair (AO30001); World Class University project of Ministry of Education, Science & Technology and the Korea Science and Engineering Foundation through Seoul National University (R31-2008-000-10103-0).
PY - 2009
Y1 - 2009
N2 - Objectives: This study was conducted to investigate the role of common variation in innate immunity-related genes as susceptibility factors to breast cancer risk in Korean women. Methods: Total 1536 single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed by Illumina GoldenGate assay in 209 cases and the same numbers of controls. Both SNP and gene-based tests were used to evaluate the association with breast cancer risk. The robustness of results was further evaluated with permutation method, false discovery rate and haplotype analyses. Results: Both SNP and gene-based analyses showed promising associations with breast cancer risk for 17 genes: OR10J3, FCER1A, NCF4, CNTNAP1, CTNNB1, KLKB1, ITGB2, ALOX12B, KLK2, IRAK3, KLK4, STAT6, NCF2, CCL1, C1QR1, MBP and NOS1. The most significant association with breast cancer risk was observed for the OR10J3 SNP (rs2494251, P-value = 1.2 × 10-4) and FCER1A SNP (rs7548864, P-value = 7.7 × 104). Gene-based permutation and false discovery rate P-values for OR10J3 SNP (rs2494251) with breast cancer risk were also significant (P = 4 × 10-5 and 0.008, respectively). Haplotype analyses supported these findings that OR10J3 and FCER1A were most significantly associated with risk for breast cancer (P = 2 × 10-4 and 0.004, respectively). Conclusion: This study suggests that common genetic variants in the OR10J3 and FCER1A be strongly associated with breast cancer risk among Korean women.
AB - Objectives: This study was conducted to investigate the role of common variation in innate immunity-related genes as susceptibility factors to breast cancer risk in Korean women. Methods: Total 1536 single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed by Illumina GoldenGate assay in 209 cases and the same numbers of controls. Both SNP and gene-based tests were used to evaluate the association with breast cancer risk. The robustness of results was further evaluated with permutation method, false discovery rate and haplotype analyses. Results: Both SNP and gene-based analyses showed promising associations with breast cancer risk for 17 genes: OR10J3, FCER1A, NCF4, CNTNAP1, CTNNB1, KLKB1, ITGB2, ALOX12B, KLK2, IRAK3, KLK4, STAT6, NCF2, CCL1, C1QR1, MBP and NOS1. The most significant association with breast cancer risk was observed for the OR10J3 SNP (rs2494251, P-value = 1.2 × 10-4) and FCER1A SNP (rs7548864, P-value = 7.7 × 104). Gene-based permutation and false discovery rate P-values for OR10J3 SNP (rs2494251) with breast cancer risk were also significant (P = 4 × 10-5 and 0.008, respectively). Haplotype analyses supported these findings that OR10J3 and FCER1A were most significantly associated with risk for breast cancer (P = 2 × 10-4 and 0.004, respectively). Conclusion: This study suggests that common genetic variants in the OR10J3 and FCER1A be strongly associated with breast cancer risk among Korean women.
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U2 - 10.1093/carcin/bgp084
DO - 10.1093/carcin/bgp084
M3 - Article
C2 - 19372141
AN - SCOPUS:70249121777
SN - 0143-3334
VL - 30
SP - 1528
EP - 1531
JO - Carcinogenesis
JF - Carcinogenesis
IS - 9
ER -