Candida tropicalis infections in children with leukemia

Patricia M. Flynn, Neyssa M. Marina, Gaston K. Rivera, Walter T. Hughes

Research output: Contribution to journalArticlepeer-review

Abstract

The Candida species account for approximately three-fourths of fungal infections in patients with cancer. Although Candida albicans is the most frequent cause, C. tropicalis is increasingly implicated as an important pathogen. Over a 12 year period 19 children treated for leukemia at our institution developed C. tropicalis infections. We describe their clinical presentation, extent of fungal infection, treatment, and outcome. Fungemia without meningitis in 11 children was treated successfully, whereas C. tropicalis meningitis in 7 children was uniformly fatal. An additional patient had unsuspected, widespread infection detected at autopsy. Multiple sites, including the cerebrospinal fluid yielded C. tropicalis. Previously reported risk factors including neutropenia, broad-spectrum antibiotic usage, corticosteroid therapy, and total parenteral nutrition were observed in our cases. A high index of suspicion and the early use of aggressive antifungal therapy are critical to the successful management of C. tropicalis infections in children with leukemia.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalLeukemia and Lymphoma
Volume10
Issue number4-5
DOIs
StatePublished - 1993

Keywords

  • Candida tropicalis
  • Fungal infection
  • Fungemia
  • Immunosuppression
  • Meningitis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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