Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans

Hyun Jun Jung, Young Bae Seu, Dong Gun Lee

Research output: Contribution to journalArticle

Abstract

Resveratrol (3,5,4′-trihydroxystilbene) is a naturally occurring, multi-biofunctional chemical existing in grapes and various other plants as a polyphenot type, and it is one of the best known natural anticancer and antiatherosclerosis reagents. In this study, we investigated the antifungal action by resveratrol in Candida albicans, which is a human infectious fungi as an agent of candidiasis. Resveratrol displayed potent fungicidal activity in an energy-dependent manner, without any hemolytic effects against human erythrocytes. It was found that the serum-induced mycelial forms, which play a crucial role in the pathogenesis of C. albicans during host tissue invasion, were disrupted by resveratrol. To understand the correlation between lethal effects and resveratrol action, we examined the physiological changes of C. albicans. A significant accumulation of intracellular trehalose was induced by stress responses to resveratrol action, and a remarkable arrest of cell-cycle processes at the S-phase in C. albicans occured. Therefore, the fungicidal effects of resveratrol demonstrate that this compound is a potential candidate as an antifungal agent in treating infectious diseases by candidal infections.

Original languageEnglish (US)
Pages (from-to)1324-1329
Number of pages6
JournalJournal of Microbiology and Biotechnology
Volume17
Issue number8
StatePublished - Aug 1 2007
Externally publishedYes

Keywords

  • Anticandidal activity
  • Candida albicans
  • Fungicidal activity
  • Phenolic antioxidant
  • Resveratrol
  • Trans-3,5,4′-trihydroxystilbene

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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