TY - JOUR
T1 - Cancer's molecular sweet tooth and the warburg effect
AU - Kim, Jung Whan
AU - Dang, Chi V.
PY - 2006/9/15
Y1 - 2006/9/15
N2 - More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have renewed discussions about its exact role as cause, correlate, or facilitator of cancer. Molecular advances in this area may reveal tactics to exploit the cancer cell's "sweet tooth" for cancer therapy.
AB - More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have renewed discussions about its exact role as cause, correlate, or facilitator of cancer. Molecular advances in this area may reveal tactics to exploit the cancer cell's "sweet tooth" for cancer therapy.
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U2 - 10.1158/0008-5472.CAN-06-1501
DO - 10.1158/0008-5472.CAN-06-1501
M3 - Article
C2 - 16982728
AN - SCOPUS:33749478922
VL - 66
SP - 8927
EP - 8930
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 18
ER -