Cancer vaccines for hematologic malignancies

Ivan M Borrello, Eduardo M. Sotomayor

Research output: Contribution to journalArticle

Abstract

Background: Improvements in the identification of tumor-associated antigens and in our understanding of the mechanisms regulating antitumor immune responses have revived interest in the use of therapeutic cancer vaccination. Due to their unique characteristics, hematologic malignancies represent an ideal target for vaccine-based therapeutic interventions. Methods: A review of published vaccine studies in experimental models as well as the results of clinical trials using vaccines for patients with hematologic tumors is presented. Results: Tumor vaccine strategies can be divided into two categories: antigen-specific strategies, in which the tumor antigens have been identified and can be isolated to develop a molecularly defined vaccine, and cellular or non-antigen-specific, in which the tumor-specific antigens are unknown but presumed to exist within the material used to generate the vaccine. Early clinical trials have shown not only the feasibility and safety of either approach but also the obstacles in therapeutic cancer vaccination as an effective treatment modality for hematologic malignancies. Conclusions: Active immunization using current cancer vaccine approaches is feasible and safe. Although no major successes have been reported, the positive clinical results observed in some patients support the potential for therapeutic cancer vaccination in the management of hematologic malignancies. Results of studies that are testing vaccine formulations, targets, and settings (eg, bone marrow transplantation) may support the use of cancer vaccination as an efficient therapeutic strategy against tumors of hematologic origin.

Original languageEnglish (US)
Pages (from-to)138-151
Number of pages14
JournalCancer Control
Volume9
Issue number2
StatePublished - 2002

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Cancer Vaccines
Hematologic Neoplasms
Vaccines
Vaccination
Neoplasm Antigens
Neoplasms
Clinical Trials
Therapeutics
Therapeutic Uses
Bone Marrow Transplantation
Theoretical Models
Safety
Antigens

ASJC Scopus subject areas

  • Oncology

Cite this

Cancer vaccines for hematologic malignancies. / Borrello, Ivan M; Sotomayor, Eduardo M.

In: Cancer Control, Vol. 9, No. 2, 2002, p. 138-151.

Research output: Contribution to journalArticle

Borrello, IM & Sotomayor, EM 2002, 'Cancer vaccines for hematologic malignancies', Cancer Control, vol. 9, no. 2, pp. 138-151.
Borrello, Ivan M ; Sotomayor, Eduardo M. / Cancer vaccines for hematologic malignancies. In: Cancer Control. 2002 ; Vol. 9, No. 2. pp. 138-151.
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