TY - JOUR
T1 - Cancer surgery in the elderly
AU - Kowdley, Gopal C.
AU - Merchant, Nishant
AU - Richardson, James P.
AU - Somerville, Justin
AU - Gorospe, Myriam
AU - Cunningham, Steven C.
PY - 2012
Y1 - 2012
N2 - The proportions both of elderly patients in the world and of elderly patients with cancer are both increasing. In the evaluation of these patients, physiologic age, and not chronologic age, should be carefully considered in the decision-making process prior to both cancer screening and cancer treatment in an effort to avoid ageism. Many tools exist to help the practitioner determine the physiologic age of the patient, which allows for more appropriate and more individualized risk stratification, both in the pre- and postoperative periods as patients are evaluated for surgical treatments and monitored for surgical complications, respectively. During and after operations in the oncogeriatric populations, physiologic changes occuring that accompany aging include impaired stress response, increased senescence, and decreased immunity, all three of which impact the risk/benefit ratio associated with cancer surgery in the elderly.
AB - The proportions both of elderly patients in the world and of elderly patients with cancer are both increasing. In the evaluation of these patients, physiologic age, and not chronologic age, should be carefully considered in the decision-making process prior to both cancer screening and cancer treatment in an effort to avoid ageism. Many tools exist to help the practitioner determine the physiologic age of the patient, which allows for more appropriate and more individualized risk stratification, both in the pre- and postoperative periods as patients are evaluated for surgical treatments and monitored for surgical complications, respectively. During and after operations in the oncogeriatric populations, physiologic changes occuring that accompany aging include impaired stress response, increased senescence, and decreased immunity, all three of which impact the risk/benefit ratio associated with cancer surgery in the elderly.
UR - http://www.scopus.com/inward/record.url?scp=84856393123&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856393123&partnerID=8YFLogxK
U2 - 10.1100/2012/303852
DO - 10.1100/2012/303852
M3 - Review article
C2 - 22272172
AN - SCOPUS:84856393123
VL - 2012
JO - The Scientific World Journal
JF - The Scientific World Journal
SN - 2356-6140
M1 - 303852
ER -