TY - JOUR
T1 - Cancer stem cells and their role in metastasis
AU - Shiozawa, Yusuke
AU - Nie, Biao
AU - Pienta, Kenneth J.
AU - Morgan, Todd M.
AU - Taichman, Russell S.
N1 - Funding Information:
We thank Drs McCauley and Keller (University of Michigan) for their helpful discussions. Figures were produced using Servier Medical Art ( www.servier.com ). This work is directly supported by the National Cancer Institute ( CA163124 , CA093900 , Y.S., K.J.P. and R.S.T.), the Fund for Cancer Research (R.T.), the Department of Defense (R.S.T.), and the Prostate Cancer Foundation (Y.S., K.J.P. and R.S.T.) the NIH SPORE in prostate cancer grant P50 CA69568 (K.J.P., R.T.).
PY - 2013/5
Y1 - 2013/5
N2 - Cancer stem cells (CSCs), which comprise a small fraction of cancer cells, are believed to constitute the origin of most human tumors. Considerable effort has been focused on identifying CSCs in multiple tumor types and identifying genetic signatures that distinguish CSCs from normal tissue stem cells. Many studies also suggest that CSCs serve as the basis of metastases. Yet, experimental evidence that CSCs are the basis of disseminated metastases has lagged behind the conceptual construct of CSCs. Recent work, however, has demonstrated that CSCs may directly or indirectly contribute to the generation of metastasis. Moreover, CSC heterogeneity may be largely responsible for the considerable complexity and organ specificity of metastases. In this review, we discuss the role of CSCs in metastasis and their potential as therapeutic targets.
AB - Cancer stem cells (CSCs), which comprise a small fraction of cancer cells, are believed to constitute the origin of most human tumors. Considerable effort has been focused on identifying CSCs in multiple tumor types and identifying genetic signatures that distinguish CSCs from normal tissue stem cells. Many studies also suggest that CSCs serve as the basis of metastases. Yet, experimental evidence that CSCs are the basis of disseminated metastases has lagged behind the conceptual construct of CSCs. Recent work, however, has demonstrated that CSCs may directly or indirectly contribute to the generation of metastasis. Moreover, CSC heterogeneity may be largely responsible for the considerable complexity and organ specificity of metastases. In this review, we discuss the role of CSCs in metastasis and their potential as therapeutic targets.
KW - Cancer stem cells
KW - Cancer therapeutic target
KW - Circulating tumor cells
KW - Epithelial to mesenchymal transition
KW - Metastasis
KW - Molecular marker
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U2 - 10.1016/j.pharmthera.2013.01.014
DO - 10.1016/j.pharmthera.2013.01.014
M3 - Review article
C2 - 23384596
AN - SCOPUS:84875219387
SN - 0163-7258
VL - 138
SP - 285
EP - 293
JO - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
JF - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
IS - 2
ER -