Cancer Stem Cell Metabolism

Fidelia B. Alvina; Arvin M. Gouw; Anne Le

doi:10.1007/978-3-030-65768-0_12

Cancer Stem Cell Metabolism

Fidelia B. Alvina, Arvin M. Gouw, Anne Le

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cancer stem cells (CSCs), also known as tumorinitiating cells (TICs), are a group of cells found within cancer cells. Like normal stem cells, CSCs can proliferate, engage in self-renewal, and are often implicated in the recurrence of tumors after therapy [1, 2]. The existence of CSCs in various types of cancer has been proven, such as in acute myeloid leukemia (AML) [3], breast [4], pancreatic [5], and lung cancers [6], to name a few. There are two theories regarding the origin of CSCs. First, CSCs may have arisen from normal stem/progenitor cells that experienced changes in their environment or genetic mutations. On the other hand, CSCs may also have originated from differentiated cells that underwent genetic and/or heterotypic modifications [7]. Either way, CSCs reprogram their metabolism in order to support tumorigenesis.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	161-172
Number of pages	12
DOIs	https://doi.org/10.1007/978-3-030-65768-0_12
State	Published - 2021

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1311
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Cancer stem cell
Glucose metabolism
Glutamine metabolism
Lipid metabolism
Metabolic plasticity
Mitochondrial metabolism

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-3-030-65768-0_12

Cite this

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title = "Cancer Stem Cell Metabolism",

abstract = "Cancer stem cells (CSCs), also known as tumorinitiating cells (TICs), are a group of cells found within cancer cells. Like normal stem cells, CSCs can proliferate, engage in self-renewal, and are often implicated in the recurrence of tumors after therapy [1, 2]. The existence of CSCs in various types of cancer has been proven, such as in acute myeloid leukemia (AML) [3], breast [4], pancreatic [5], and lung cancers [6], to name a few. There are two theories regarding the origin of CSCs. First, CSCs may have arisen from normal stem/progenitor cells that experienced changes in their environment or genetic mutations. On the other hand, CSCs may also have originated from differentiated cells that underwent genetic and/or heterotypic modifications [7]. Either way, CSCs reprogram their metabolism in order to support tumorigenesis.",

keywords = "Cancer stem cell, Glucose metabolism, Glutamine metabolism, Lipid metabolism, Metabolic plasticity, Mitochondrial metabolism",

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doi = "10.1007/978-3-030-65768-0_12",

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T1 - Cancer Stem Cell Metabolism

AU - Alvina, Fidelia B.

AU - Gouw, Arvin M.

AU - Le, Anne

PY - 2021

Y1 - 2021

N2 - Cancer stem cells (CSCs), also known as tumorinitiating cells (TICs), are a group of cells found within cancer cells. Like normal stem cells, CSCs can proliferate, engage in self-renewal, and are often implicated in the recurrence of tumors after therapy [1, 2]. The existence of CSCs in various types of cancer has been proven, such as in acute myeloid leukemia (AML) [3], breast [4], pancreatic [5], and lung cancers [6], to name a few. There are two theories regarding the origin of CSCs. First, CSCs may have arisen from normal stem/progenitor cells that experienced changes in their environment or genetic mutations. On the other hand, CSCs may also have originated from differentiated cells that underwent genetic and/or heterotypic modifications [7]. Either way, CSCs reprogram their metabolism in order to support tumorigenesis.

AB - Cancer stem cells (CSCs), also known as tumorinitiating cells (TICs), are a group of cells found within cancer cells. Like normal stem cells, CSCs can proliferate, engage in self-renewal, and are often implicated in the recurrence of tumors after therapy [1, 2]. The existence of CSCs in various types of cancer has been proven, such as in acute myeloid leukemia (AML) [3], breast [4], pancreatic [5], and lung cancers [6], to name a few. There are two theories regarding the origin of CSCs. First, CSCs may have arisen from normal stem/progenitor cells that experienced changes in their environment or genetic mutations. On the other hand, CSCs may also have originated from differentiated cells that underwent genetic and/or heterotypic modifications [7]. Either way, CSCs reprogram their metabolism in order to support tumorigenesis.

KW - Cancer stem cell

KW - Glucose metabolism

KW - Glutamine metabolism

KW - Lipid metabolism

KW - Metabolic plasticity

KW - Mitochondrial metabolism

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ER -

Cancer Stem Cell Metabolism

Abstract

Publication series

Keywords

ASJC Scopus subject areas

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